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  • Digitale Medien  (3)
  • Polymerase chain reaction  (2)
  • Adenosine  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Adenosine induced fall in glomerular capillary pressure (1981)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 317 (1981), S. 86-89 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Glomerular capillary pressure ; Munich-Wistar rat ; Adenosine ; Ureteral obstruction ; Aortic constriction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effect of acute ureteral obstruction (UO) and reduction of renal artery pressure (AC) on the adenosineinduced renal vasoconstriction was studied in the Munich-Wistar rat. Infusion of adenosine, 0.05 μmol/min · kg body weight, into the thoracic aorta, was associated with a fall of directly measured glomerular capillary pressure (P gc) from 45.2+1.8 to 32.5+1.7 mm Hg, P〈0.001. Elevation of ureter pressure to 39+2 mm Hg abolished the fall of P gc following adenosine infusion, 51.3+1.7 vs. 50.0+1.3 mm Hg, NS. Reduction of renal artery pressure to 70 mm Hg by an aortic clamp above the renal arteries also prevented the fall of P gc due to adenosine, 36.8+0.9 vs. 36.4+1.8 mm Hg, NS. Administration of indometacin (10 mg/kg i.v.) restored the ability of adenosine to reduce P gc in UO from 41.5+1.1 to 25.9+2.6 mm Hg (P〈0.001) and in AC from 34.0+3.4 to 28.2+75.7 mm Hg (P〈0.02). Since previous studies have demonstrated that in UO and AC renal prostaglandin synthesis is enhanced the effects of indometacin suggest that prostaglandins could be antagonistic to the action of adenosine on the kidney. The data show that the renal vasculature becomes insensitive to the vasoconstrictive action of adenosine during elevated ureter pressure and reduced renal artery pressure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00506263
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  • 2
    Digitale Medien
    Digitale Medien
    Wertigkeit der Polymerase-Kettenreaktion (PCR) für die Diagnostik der tuberkulösen Meningitis (1998)
    Springer
    Der Nervenarzt 69 (1998), S. 502-506 
    Details
    ISSN: 1433-0407
    Schlagwort(e): Schlüsselwörter Tuberkulöse Meningitis ; Polymerase- Kettenreaktion ; Liquor ; Mycobacterium tuberculosis ; Mycobacterium fortuitum ; Key words Tuberculous meningitis ; Polymerase chain reaction ; Mycobacteria tuberculosis ; Mycobacteria fortuitum
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: , alsein ubiquitärer Keim mit geringer Pathogenität, Untersuchungsproben verunreinigen kann und die Verwendung von Primerpaaren, die gruppenspezifische mykobakterielle DNA erkennen, zu falsch-positiven Resultaten führen kann. Für die Validität der PCR ist daher neben der Sensitivität der Nachweisreaktion, die Spezifität der eingesetzten PCR-Primer von großer Bedeutung, um zwischen mykobakteriellen Subtypen zu differenzieren.
    Kurzfassung: Value of the polymerase chain reaction (PCR) for diagnosing tuberculous meningitis
    Notizen: Zusammenfassung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001150050304
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  • 3
    Digitale Medien
    Digitale Medien
    Comparative analysis of intrathecal antibody synthesis and DNA amplification for the diagnosis of cytomegalovirus infection of the central nervous system in AIDS patients (1994)
    Springer
    Journal of neurology 241 (1994), S. 407-414 
    Details
    ISSN: 1432-1459
    Schlagwort(e): Cytomegalovirus ; Acquired immunodeficiency syndrome ; Recombinant phosphoprotein (pp150) ; Intrathecal antibody synthesis ; Polymerase chain reaction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We evaluated 49 paired cerebrospinal fluid (CSF) and serum samples of 35 patients infected with the human immunodeficiency virus type 1 (HIV-1) for laboratory evidence of cytomegalovirus (CMV) infection. The patients were grouped according to clinical criteria as probable CMV encephalitis/polyradiculomyelitis, CMV retinitis, cerebral toxoplasmosis, progressive multifocal leukoencephalopathy, HIV-1-related cognitive/motor complex, HIV-1-associated myelopathy, and other neurological diseases. Paired CSF and serum samples were analysed for CMV deoxyribonucleic acid (DNA) by polymerase chain reaction (PCR), quantitative intrathecal synthesis of immunoglobulin G (IgG) antibodies specific for recombinant phosphoprotein 150 (pp150) of CMV and CMV-specific serum IgM. Intrathecal synthesis of pp150-specific IgG was detected in 26% of patients (9/35), serum IgM was found in 23% of patients (8/35), and PCR of CSF was positive in 11% of patients (4/35). Detection of CMV-specific DNA in CSF preceded the intrathecal antibody synthesis in three patients for whom serial samples were available. PCR results of the CSF became negative in one patient with CMV polyradiculomyelitis after successful therapy with 9-[2-hydroxy-l(hydroxymethyl) ethoxymethyl] guanine (DHPG). PCR has a higher diagnostic specificity in the acute phase of CMV infection than intrathecal antibody synthesis. The serum IgM response to CMV cannot be used to monitor a compartmentalized immune response in the central nervous system while an intrathecal immune response seems to be associated with recovery either spontaneously or as a result of treatment.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00900957
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