Electronic Resource
Springer
Naunyn-Schmiedeberg's archives of pharmacology
306 (1979), S. 101-103
ISSN:
1432-1912
Keywords:
Prostacyclin (PGI2)
;
Cyclic AMP
;
Adenosine
;
Noradrenaline
;
Coronary arteries
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effects of prostacyclin (PGI2) on vascular tension and cAMP content were measured in isolated bovine coronary artery strips. 3 nM PGI2 did not alter the tension but diminished the cAMP content by 56% of the control level (P〈0.005). 30 and 300 nM PGI2 diminished the tension and further reduced the cAMP content, which amounted to only 5% of the control at 300 nM PGI2. These results are in contrast to the increase in cAMP level by PGI2 in blood platelets and might indicate a different mechanism of action of PGI2 in platelets and vascular tissue.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00515602
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