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  • 1
    Electronic Resource
    Electronic Resource
    Detection of antibodies to adult T-cell leukemia (ATL)-associated virus in ATL patients' sera by immunoelectron microscopy (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 240-243 
    Details
    ISSN: 1432-1335
    Keywords: Adult T-cell leukemia virus ; Adult T-cell leukemia-associated antibodies ; Adult T-cell leukemia patients' sera ; Immunoelectron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In an attempt to demonstrate the presence of antibodies to ATL-associated type-C virus particles (ATLV), an indirect immunoferritin method of immunoelectron microscopy was performed on an ATLV-producing human cord T-cell line (MT-2) and short-term cultures of ATL cells. All five sera from ATL patients seropositive to ATL-associated antigens (ATLA) but not three sera from healthy adults were positive for the ferritin labeling of ATLV and plasma membranes in both MT-2 and short-term cultured ATL cells. Sera absorbed with sheep red blood cells or human T-cell acute lymphatic leukemia cells labeled ATLV much more intensely with ferritin than with plasma membranes. These results demonstrated at the ultrastructural level that anti-ATLA-positive sera contained antibodies to surface glycoproteins and/or structural proteins of ATLV and that they differed from anti-Forssman or anti-T-cell antibodies. It was also demonstrated that anti-ATLA-positive sera showed the same reactivity with ATLV from both MT-2 and short-term cultured ATL-cells by the immunoferritin method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402615
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Activation of an endogenous oncogenic virus by human adenovirus in mice (1979)
    Springer
    Journal of cancer research and clinical oncology 93 (1979), S. 45-56 
    Details
    ISSN: 1432-1335
    Keywords: Activation ; Endogenous virus ; Adenovirus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intracisternal A and C particles were abundant in adenovirus 12-induced primary and serially transplanted tumors in C3H/BifB mice. Malignant lymphomas were induced in 12 of 40 mice between 8–18 months when viral particulates from the tumor were inoculated into homologous newborn mice. This malignant lymphoma was morphologically different from the adenovirus 12-induced tumor from which the extract was prepared. Only a few of these viruses were observed in mice of the same strain in spontaneous hepatoma, 4-nitro-quinoline 1-oxide-induced fibrosarcoma and squamous cell carcinoma. In virus-induced malignant lymphoma adenovirus 12-specific tumor antigen was not evident by immunofluorescent method, whereas the antigen was recognized as flecks in the adenovirus 12-induced tumor cell cytoplasm. However, the localization of the fluorescent positive antigen did not coincide with the election microscopic site of the virus. The endogenous RNA type virus virogene C and/or intracisternal A may be activated by adenovirus 12 along with the carcinogenesis and appear in the tumor cell. These viruses may then induce malignant lymphoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00451439
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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