ISSN:
1432-1238
Keywords:
Key words Amiodarone
;
Acute amiodarone
;
Induced pulmonary toxicity (APT)
;
Adult respiratory distress syndrome (ARDS)
;
Ventilation
;
High oxygen concentrations
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Objective: To investigate any relationship between the pathological features of amiodarone-induced pulmonary toxicity (APT) and clinical use of amiodarone in patients dying from acute respiratory distress syndrome (ARDS). Design: Retrospective study. Review of clinical and pathological findings of patients dying from ARDS. Setting: Intensive Care Unit (ICU) and Pathology Department of University hospital. Subjects: Ten patients with clinical diagnosis of ARDS, who died in ICU and underwent post mortem examination. Interventions: Case note review of clinical details; independent review of histological specimens. Measurement and results: Over a 3-year period, ten patients underwent post mortem examination, of whom seven had received amiodarone. Three patients who received longer than 48 h of amiodarone had histological changes of widespread lipoid pneumonia, a recognised pattern of APT. Conclusions: Acute amiodarone pulmonary toxicity is a definite pathological entity in ICU patients. High oxygen concentrations may be a risk factor, while pre-existing pathology, e. g. ARDS, may mask its development. Amiodarone should be used with caution in this group of patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001340050627
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