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  • 1
    ISSN: 1573-1561
    Keywords: Alpha-terthienyl ; Aedes aegypti ; Diptera ; Culicidae ; photosensitization ; insecticide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Alpha-terthienyl is toxic toAedes aegypti larvae in the dark, but its activity is much enhanced in the presence of ultraviolet light. The development of first-instar larvae treated with alpha-terthienyl and ultraviolet light was followed until the emergence of adults. The LC50 value for first instars was about 0.002 ppm. Practically all the larvae which survived 24 hr reached adulthood. Fourth-instar larvae were also sensitive to photochemical treatment. When their development into adults was followed, the LC50 value was 0.45 ppm. Contrary to earlier reports, alpha-terthienyl was also phototoxic in pupae, but not when the adults were about to emerge. The LC50 value was ca. 0.06 ppm for pupae which were 1 or 2 days old. This is the first example where the activity of a photoinsecticide has been demonstrated in pupae. Alpha-terthienyl did not affect the hatching of eggs.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-1561
    Keywords: Phototoxicity ; 8-methoxypsoralen ; sphondin ; khellin ; Aedes aegypti ; Diptera ; Culicidae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract At concentrations up to 6.7 ppm, 8-methoxypsoralen, sphondin, and khellin are not toxic to first-instar larvae of the mosquitoAedes aegypti. The irradiation of sensitized larvae with long-wavelength ultraviolet light did not always produce any immediate toxicity enhancement, but delayed effects were clearly visible. These were observed over the development of the organisms from first-instar larvae to adults. No adverse effects were noted when larvae were irradiated in the absence of sensitizers, or when they were placed in solutions of sensitizers which had been previously irradiated with the same light sources. 8-Methoxypsoralen was slightly more phototoxic than its isomer sphondin. Khellin, recently reported to undergo photoinduced cyclization with DNA components, showed minimal phototoxicity in the concentration range used.
    Type of Medium: Electronic Resource
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