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  • 1
    Electronic Resource
    Electronic Resource
    Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes (1999)
    Springer
    Molecular genetics and genomics 262 (1999), S. 220-229 
    Details
    ISSN: 1617-4623
    Keywords: Key words Mammalian Dbf4 ; Cdc7 kinase ; MCM2 ; Initiation of DNA replication ; Cell cycle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The kinase Dbf4p/Cdc7p is required for the G1/S phase transition during the cell cycle and plays a direct role in the activation of individual origins of replication in Saccharomyces cerevisiae. Here, we report the identification and characterization of mouse and human cDNAs whose products are related in sequence to Saccharomyces cerevisiae DBF4 cDNA. Both mammalian Dbf4 proteins contain a putative site for phosphorylation by CDK, PEST protease cleavage sites, nuclear localization signals and a short-looped zinc finger-like domain. Transcription of MmDBF4 is suppressed in mouse NIH3T3 fibroblasts made quiescent by serum starvation. Upon replenishment of the medium, transcript levels increase during progression through G1, peaking as cells enter S phase. MmDbf4p interacts physically with Cdc7p and Mcm2p in vivo. Using fluorescence in situ hybridization (FISH), the human DBF4 gene was localized to chromosome 7 (q21.3), whereas FISH mapped the murine counterpart to band A2 on chromosome 5. The results of chromosome mapping indicate that in both mouse and human the gene is present as a single copy. The structural conservation between Dbf4-related proteins suggests that these proteins play a key role in the regulation of DNA replication during the cell cycle in all eukaryotes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380051078
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  • 2
    Electronic Resource
    Electronic Resource
    Improvement of the empirical thermospheric model DTM: DTM94 – a comparative review of various temporal variations and prospects in space geodesy applications (1998)
    Springer
    Journal of geodesy 72 (1998), S. 161-178 
    Details
    ISSN: 1432-1394
    Keywords: Key words. Thermosphere models ; Non-gravitational forces ; Air drag ; Orbit determination ; Space geodesy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying
    Notes: Abstract. The Drag Temperature Model (1978) has been improved to respond better to the actual requirements of space geodesy, especially under extreme solar and geomagnetic conditions. Extended data and an improved algorithm have been considered, leading to valuable improvements. Temporal variations of temperature of the thermopause, total density and major chemical constituent density are reviewed and compared to the DTM94, DTM78 and MSIS86 models. A comparison with data is performed, giving the mean ratios between observed and model values with their root mean squares for different physical and geometric conditions. This comparison is made for the three models and includes data used in the modelling as well as external data. The limits of the thermosphere modelling are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001900050158
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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