Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 14 (1986), S. 401-415 
    ISSN: 1573-9686
    Keywords: Linear-lumped-parameter modeling ; Parameter optimization ; Frequency dependence ; Airway wall compliance ; Lung mechanics ; Comparative respiratory mechanics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Pulmonary impedance, ZL, measured from 2 to 32 Hz in anesthetized, intubated and paralyzed bonnet monkeys (Macaca radiata) was fitted to a variety of linearlumped parameter mechanical networks. Parameter values for each network were obtained by minimizing the average of the percent distance, Dr, between the computed network impedance and measured ZL at all frequencies. Measured resistance, RL, decreased from 2 to 8 Hz and increased from 8 to 32 Hz indicating that a single series resistance-inertance-compliance (RIC) network was not optimal (Dr∼19%). Networks consisting of two series RIC pathways in parallel resulted in a lower Dr (∼14%), but parameter values were difficult to interpret. Despite not modeling the decrease in RL with frequency below 8 Hz, an airway wall compliance, C aw , network in which the airways were separated into central and peripheral components resulted in an even lower Dr (∼11%). In addition, parameter values were easy to interpret, consistent among our “normal” monkeys and changed consistently and explainably with change in lung mechanics induced by decrease in lung volume. We conclude that (1) networks containing both parallel pathways and C aw are necessary to model ZL over the entire frequency range (2–32 Hz), (2) the effect of C aw is an important determinant of ZL above 8 Hz, and (3) a six-parameter C aw network with the ratio of C aw to parenchymal compliance, Cp, fixed may prove useful in interpreting changes in ZL induced by alterations in lung mechanics in monkeys.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...