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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 284 (1992), S. 297-302 
    ISSN: 1432-069X
    Keywords: Allergic contact dermatitis ; Murine model ; Helenin ; Alantolactone ; Isoalantolactone ; Cross-reaction ; Lymphocyte transformation test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The use of a lymphocyte transformation test (LTT) to provide evidence of allergic contact dermatitis was investigated. The haptens studied were alantolactone and isoalantolactone, two moderate allergens from Inula helenium L., a decorative and medicinal plant. Only alantolactone showed a significant response in vivo and in vitro in mice sensitized epicutaneously, without using Freund's complete adjuvant. Isoalantolactone did not show any sensitizing capacity in the murine model studied. The comparison of in vitro lymphocyte proliferation and in vivo allergenic capacity showed a good correlation and clearly demonstrates that, of the two sesquiterpene lactones, alantolactone is the better sensitizer.
    Type of Medium: Electronic Resource
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