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Platelet factor 4 regulates osteoclastic bone resorption in vitro

Horton, J.E. ; Harper, J. ; Harper, E.

Amsterdam : Elsevier

Biochimica et Biophysica Acta (BBA)/General Subjects 630 (1980), S. 459-462

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ISSN: 0304-4165

Keywords: Bone resorption ; Ca^2^+ release ; Osteoclast ; Parathyroid hormone ; Platelet factor 4

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Medicine , Physics

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0304-4165(80)90295-0

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Isolation and partial characterization of conditional cell division cycle mutants inChlamydomonas (1995)

Harper, J. D. I. ; Wu, L. ; Sakuanrungsirikul, S. ; [et al.]

Springer

Protoplasma 186 (1995), S. 149-162

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ISSN: 1615-6102

Keywords: Algae ; Cytoskeleton ; Microtubules ; Microtubule organizing centres ; Mutation ; Temperature-sensitive

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Summary We have isolated a number of temperature conditional cell division cycle mutants of the unicellular plantChlamydomonas reinhardtii that are defective in single nuclear genes. Cells grow and divide normally at the permissive temperature (21 °C), but arrest in division at the restrictive temperature (33 °C). We have characterized these mutants using DNA probes and immunofluorescence techniques to localize cytoskeletal and microtubule organizing centre proteins. We describe here 3 broad classes of cell cycle mutation which result in cell cycle arrest with: unreplicated DNA (G1 arrest), duplicated DNA (G2 arrest) and multiple nuclei due to defective cytokinesis (cytokinesis arrest). The continuation of nuclear division in mutants blocked in cytokinesis provides support of an earlier hypothesis that stage specific events in theChlamydomonas cell cycle are arranged in separate dependent sequences. The mutants isolated in the present study provide insights into the role of cytoskeletal proteins in the coordination of plant cell division and the means to investigate the molecular mechanisms whereby division by multiple fission is controlled in the unicellular plantChlamydomonas.