Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Freisetzung von Serotonin und Histamin aus Thrombocyten durch aliphatische und aromatische Amine (1969)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 265 (1969), S. 24-48 
    Details
    ISSN: 1432-1912
    Keywords: Thrombocytes ; Serotonin ; Histamine ; Aliphatic Amines ; Amine Liberation ; Thrombocyten ; Serotonin ; Histamin ; Aliphatische Amine ; Aminfreisetzung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In studies with washed platelets and with platelet-rich plasma of the rabbit the following results were obtained: 1. Incubation of thrombocytes withaliphatic amines having different lengths of the carbon chain (C6-C10) produced a dose-dependent decrease of the serotonin and histamine content of the cells. Amines with a long carbon chain (e.g. C10, C9) were 10–20 times more effective than those having a short chain length (e.g. C6, C7). While C10 and lysolecithin lead to an approximative equal decrease in serotoninand histamine content of the cells, C6 mainly induced a liberation of serotonin. Incubation of the cells with C10 or lysolecithin induced a very rapid amine liberation, while C6 and C7 had a slow amine releasing action upon the platelets. 2. Aromatic amines (e.g. phenylethylamine, tyramine) showed a selective and dose-dependent liberation of serotonin from the thrombocytes; only very high concentrations (e.g. 1.2 mg/ml) also reduced the histamine level. Introduction of a second phenolic hydroxyl group in the ring (catechol derivatives) or of an alcoholic hydroxyl group into the side chain diminished the serotonin liberating effect of the amines. Methylation of the amine group or of the alpha-carbon atom of the side chain did not influence their efficacy. — Cocaine or desmethylimipramine had no inhibitory effect upon the serotonin liberation induced by tyramine. 3. It is assumed, that thehistamine liberation induced by aliphatic amines is the result of a cytolysis,-very similar to the action of lysolecithin; this histamine liberating action corresponds to the hemolytic and surface-active properties of these substances.-In contrast, the selective and preferentialLiberation of serotonin by aromatic amines and by aliphatic amines with a short carbon chain is very likely due to a displacement of serotonin from the storage sites in the intact cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01417208
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Über β-(1,2,3-Triazolyl-4)-acroleine. II. Darstellung von β-(1-Alkyl-1,2,3-triazolyl-4)-acroleinen durch einfache Pyridinringspaltung (1966)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 33 (1966), S. 54-60 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Durch Quaternierung von 3-Acetylamino-pyridin sind N-Alkyl-3-acetylamino-pyridinium-bromide zugänglich. Die daraus durch saure Verseifung erhaltenen N-Alkyl-3-amino-pyridiniumsalze liefern bei der Diazotierung β-(1-Alkyl-1,2,3-triazolyl-4)-acroleine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19660330105
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Über β-(1,2,3-Triazolyl-4)-acroleine. III. Carbonyl--Methylen-Kondensationen mit β-(1-Aryl/Alkyl-1,2,3-triazolyl-4)-acroleinen Darstellung von 1,2,3-Triazolo-Polymethinen (1967)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 36 (1967), S. 202-224 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Durch Kondensation von β-(1-Aryl-)- und β-(1-Alkyl-1,2,3-triazolyl-4)-acroleinen mit einer Anzahl von methylenaktiven Verbindungen entstehen Polymethine der 1,2,3-Triazolreihe. Diese teils neutralen, teils kationischen Farbstoffe absorbieren in relativ niedrigen Wellenbereichen des sichtbaren Spektrums. Es wurden wesentlich kleinere “Vinylensprünge” als bei den echten Cyaninfarbstoffen gefunden. Damit offenbaren die hergestellten Polymethine ein polyenartiges Lichtabsorptionsverhalten, hervorgerufen durch den wenig basischen, jedoch ausgesprochen aromatischen Charakter der 1,2,3-Triazolringes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19670360311
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...