ISSN:
1433-8580
Keywords:
Bone metabolism
;
Vanadium
;
Zinc
;
Rat femur
;
Calcium
;
Alkaline phosphatase
;
DNA
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effect of vanadium on bone metabolism was investigated in the femoral diaphysis of weanling rats. Vanadium pentoxide (1.0–20.0 µmol V/100g b.wt.) was administered orally for 3 days. The doses of 15.0 and 20.0 µmol V/100 g caused a significant increase in serum calcium concentration. Bone alkaline phosphatase activity was increased significantly by the doses of 1.0–20.0 µmol V/100g, while bone acid phosphatase activity was not altered significantly. Bone DNA content was increased significantly by the dose of 1.0–10.0 µmol V/100 g. Bone calcium content was not altered significantly by administration of vanadium. The increase in serum calcium concentration caused by administration of vanadium (20.0 µmol/100 g) was prevented completely by simultaneous injection of zinc sulfate (15.3 µmol Zn/100 g) for 3 days, although zinc alone did not have any effect. Administration of zinc (15.3 µmol/100g) produced an appreciable increase in bone alkaline phosphatase activity, DNA content, and calcium content. These increases were not enhanced significantly by simultaneous injection of vanadium (2.0 and 20.0 µmol V/100 g). The present study indicates that a comparatively low dose of vanadium may play a nutritional role in bone formation of weanling rats, and that zinc can prevent the relevation of the toxic effect of vanadium with higher doses.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01856029
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