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  • Alkylphosphocholine  (2)
  • Alkylglycerols  (1)
  • Inorganic Chemistry  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Synthetic phospholipids as substrates for phospholipase C from Bacillus cereus
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism 1125 (1992), S. 166-170 
    Details
    ISSN: 0005-2760
    Schlagwort(e): Alkylphosphocholine ; Diacylglycerol ; Lysophospholipid ; Phospholipase C ; Synthetic phospholipid
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Medizin , Physik
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2760(92)90041-S
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  • 2
    Digitale Medien
    Digitale Medien
    Blut-Hirnschranke und Penetration von Zytostatika (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 565-571 
    Details
    ISSN: 1432-1440
    Schlagwort(e): Blood-brain barrier ; Drug transfer ; Alkylglycerols
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The penetration of 12 commonly used anticancer agents through the blood-brain barrier (BBB) was measured in a rat model using a single-injection tissue-sampling technique. Two of the tested drugs penetrated the barrier, but only to a limited extent. Entry of the drugs into the brain tissue critically depends on molecular weight and lipophilia of the respective test compound. For drugs with a molecular weight of less than 500, BBB simply behaves like an oil/water interphase, whereas drugs with a molecular weight greater than 500 are practically excluded from transport through the BBB even if they show a favourable oil/water partition coefficient. However, permeability of cytostatics was strongly increased if short chain alkylglycerols, up to final concentrations of about 0.3 mol/l were added to the injected solution. Under these conditions the Brain-Uptake-Index (BUI) reached values up to about 50% (cyclophosphamide), depending on lipid solubility and molecular dimension of the respective test compound and the alkyl chain length of the glycerol derivative.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01733202
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  • 3
    Digitale Medien
    Digitale Medien
    Pharmacokinetic behavior and antineoplastic activity of liposomal hexadecylphosphocholine (1994)
    Springer
    Cancer chemotherapy and pharmacology 34 (1994), S. 393-398 
    Details
    ISSN: 1432-0843
    Schlagwort(e): Liposomes ; Alkylphosphocholine ; Pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Hexadecylphosphocholine (HePC) shows remarkable antineoplastic efficacy in Sprague-Dawley rats bearing methylnitrosourea-induced mammary carcinoma. Unfortunately, this is accompanied by detrimental side effects that include gastrointestinal damage, body weight loss, and thrombophlebitis after i.v. injection, which has precluded the use of the HePC in humans, where nausea and vomiting can occur at noneffective dose levels. We have developed small unilamellar vesicles (SUVs) composed of HePC, cholesterol, and 1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol, which can be given p. o. and i.v. In contrast to the free drug, the toxicity of liposomal HePC is shown to be greatly reduced, and there is no risk of thrombophlebitis. Single administration of equimolar HePC doses results in differing pharmacokinetic values for free HePC (p. o.) and HePC-SUVs (p. o., i.v.).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00685563
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  • 4
    Digitale Medien
    Digitale Medien
    Ueber den Ultramarin (1872)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 5 (1872), S. 893-896 
    Details
    ISSN: 0365-9496
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/cber.18720050289
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