Electronic Resource
Springer
European archives of oto-rhino-laryngology and head & neck
212 (1976), S. 171-177
ISSN:
1434-4726
Keywords:
Dipyridamol
;
Allopurinol
;
Noise-induced Cochlear Damage/Lärmhörschäden
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Dipyridamol has in addition to a coronardilatating effect an antithrombotic one too. Moreover it facilitates the release of O2 from haemoglobin by increase of the concentration of 2,3-diphosphoglycerate in the erythrocytes. Allopurinol causes a potential resynthesis of ATP in the cells by inhibition of the metabolism of uric acid. Both substances therefore seemed to be suitable for a medicamental therapy of the noise-induced cochlear damage. The expected favourable effect of Dipyridamol and Allopurinol on the organ of Corti after sound exposure (RMP-measurement before and after exposure to pure tone 120 dB SPL) however had not been confirmed by experiment on animals (guinea Pig).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00456694
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