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  • 1
    Digitale Medien
    Digitale Medien
    The ultrastructural localization of sulfated proteoglycans is identical in the amyloids of Alzheimer's disease and AA, AL, senile cardiac and medullary carcinoma-associated amyloidosis (1989)
    Springer
    Acta neuropathologica 78 (1989), S. 202-209 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Alzheimer's disease ; Amyloid ; Neuritic plaque ; Neurofibrillary tangle ; Proteoglycans
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The cationic dyes cuprolinic blue and ruthenium red were used to ultrastructurally localize proteoglycans (PGs) within the neuritic plaque and neurofibrillary tangle of Alzheimer's disease. Highly sulfated PGs were specifically localized to the amyloid fibril of the neuritic plaque and the paired filaments of the neurofibrillary tangle. This demonstrates that highly sulfated PGs either comprise part of the Alzheimer's amyloid fibril and paired filament or are intimately associated with them. Four unrelated types of amyloid — AA (inflammation-associated), AL (immunoglobulin light chain), senile cardiac (prealbumin) and medullary carcinoma-associated amyloid (procalcitonin) — showed an identical pattern of localization of highly sulfated PG to the different amyloid fibrils. This constant close spatial relationship between PGs and diverse amyloid proteins suggests that PGs may play a role in amyloidogenesis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00688210
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Desbuquois syndrome (1991)
    Springer
    European journal of pediatrics 150 (1991), S. 793-796 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Multiple joint dislocation ; Prominent eyes ; Dwarfism ; Deviated digits ; Desbuquois syndrome ; Autosomal recessive inheritance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Three patients with short stature, joint laxity, and peculiar pelvic radiology are described. The first case is similar to those described by Desbuquois et al. [3], with deviation of digitis and supernumerary metacarpal bones. The other two children are less severely affected and are compared with others reported in literature. The authors suggest the homogeneity of the Desbuquois syndrome in spite of the variability of expression.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02026714
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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