ISSN:
1432-0533
Keywords:
Neurofibrillary tangles
;
Paired helical filaments
;
Amyloid-like
;
Neurofilaments
;
Alzheimer's disease
;
Immunohistochemistry
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The immunohistological properties of Alzheimer's neurofibrillary tangles (NFT) were studied by immunofluorescence with neurofilament (NF) antisera and with antiserum raised to paired helical filaments (PHF) in NFT preparations, brain smears, and cryostat sections. NFT decorated by NF antisera were Congo red-negative. Conversely, PHF antisera stained Congo red-positive NFT but failed to decorate NF-positive NFT. It is concluded that NF do not cross react with typical NFT, i.e., NFT displaying amyloid-like birefringence, under the conditions reported in this study.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00688115
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