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Rotations induced by L-dopa in parkinsonian rats are reduced by an ingestion of amino acids (1993)

Mizuta, E. ; Kuno, S.

Springer

Journal of neural transmission 6 (1993), S. 211-214

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ISSN: 1435-1463

Keywords: Amino acid ; L-dopa ; Parkinson's disease ; rat ; rotation

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary We studied the effect of amino acid load on L-dopa-induced rotational behavior in rats with unilateral lesion of the nigrostriatal pathway. Pretreatment of rats with an ingestion of high concentration of amino acids significantly reduced the number of rotations induced by subcutaneously injected L-dopa. These results provide the experimental basis for clinical observations that dietary protein affects the response to L-dopa in parkinsonian patients.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02260923

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