ISSN:
1432-072X
Keywords:
Amino acid transport
;
Yeast genetics
;
Multiple drug resistance
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract In order to obtain strains of Saccharomycopsis lipolytica impaired in the active transport of l-lysine, mutants resistant to a mixture of l-canavanine, l-4-5-transdehydrolysine and l-S-amino ethylcysteine, taken either all three or two by two, were isolated. These compounds were shown previously to be competitive inhibitors of l-lysine uptake. The resistance patterns and excretion capacity of the mutants were established. All mutants behaved as monogenic. Recombination tests indicated that four genes at least were involved. All mutants were impaired in both high and low affinity l-lysine transport systems. Several hypotheses on the functions of these genes are put forward and discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00411361
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