ISSN:
1573-1111
Keywords:
Amino acids
;
crown ethers
;
cryptands
;
complexes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Complex formation between several crown ethers and the cryptand (222) and α-amino acids in methanol was studied by calorimetric titration. The ligand structure and the donor atoms of the ligands play an important role in determining the measured values of the reaction enthalpies and entropies. However, with the exception of the diaza crown ether (22) all stability constants are of the same order of magnitude. The enthalpic and entropic contributions to the stabilities of the complexes formed compensate each other. In methanolic solution the amino acids exist in their zwitterionic form. This equilibrium can be influenced. Under acidic, neutral or basic conditions different values of the reaction enthalpies are measured for the complexation of some amino acids with 18-crown-6. These results demonstrate that the concentration of the zwitterionic form of the α-amino acids can be influenced. Thus the reaction between macrocyclic and macrobicyclic ligands and amino acids should be described by at least two different reaction schemes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1007941023186
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