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  • 1
    Electronic Resource
    Electronic Resource
    S-[2-Carboxy-1-(1H-imidazol-4-yl)ethyl]cysteine in normal human urine (1991)
    Springer
    Amino acids 1 (1991), S. 259-262 
    Details
    ISSN: 1438-2199
    Keywords: Amino acids ; Human urine ; Paper electrophoresis ; Cysteine ; Imidazole compound
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A compound, which had the same mobility on a high-voltage paper electrophoretogram and the sameR F value on a thin-layer chromatogram as those ofS-[2-carboxy-1-(1H-imidazol-4-yl)ethyl]cysteine (I), was partially purified from human urine by ion-exchange column chromatography. The compound gave a signal at m/z 260 on its FAB mass spectrum, which was assigned as MH+ of compound I. These results suggest that the urinary compound is compound I and it is a physiological precursor of 3-[(carboxymethyl)thio]-3-(1H-imidazol-4-yl)propanoic acid [Kinuta et al., (1991) Biochem J 275: 617–621].
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00806924
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Stratum corneum sphingolipids and free amino acids in experimentally-induced scaly skin (1992)
    Springer
    Archives of dermatological research 284 (1992), S. 363-367 
    Details
    ISSN: 1432-069X
    Keywords: Sphingolipids ; Ceramide ; Scaly skin ; Amino acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Stratum corneum sphingolipids are of particular importance in maintaining the water permeability barrier of mammalian epidermis. Free amino acids also play an important role in water retention in the stratum corneum. To clarify the way in which these substances affect scaly skin, stratum corneum sphingolipids and free amino acids collected from artificially-induced scaly skin were analysed. Scaly skin was induced by tape stripping. The total amount of sphingolipids was quantified by gas chromatography and five of sphingolipid fractions were isolated and quantified by thin-layer chromatography. Free amino acids were analysed using a high-speed amino analyser. The total amount of sphingolipid in scaly skin did not differ statistically from that in control skin. However, a significant change in the distribution of the five sphingolipid species was observed in scaly skin and the total amount of amino acids was decreased in scaly skin. These results suggest that the distribution of these five types of sphingolipid and the total amount of amino acids are responsible for scaly skin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00372041
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    Paper (German National Licenses)
    Fulltext
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