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  • 1
    Electronic Resource
    Electronic Resource
    The influence of beta-adrenoceptor antagonists with and without partial agonist activity on exercise tolerance and muscle lactate production (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 415-417 
    Details
    ISSN: 1432-1041
    Keywords: Epanolol ; metoprolol ; beta adrenoceptor antagonist ; exercise ; lactate ; intrinsic activity ; blood pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Epanolol is a beta-adrenoceptor antagonist with partial agonist activity, a property which could be useful in reducing the fatigue associated with beta blockers. In a double-blind, randomized, crossover study we have investigated the effects of metoprolol 100 mg b.d., epanolol 100 mg b.d., and epanolol 200 mg b.d. on blood pressure, heart rate, and exercise-induced fatigue in 10 hypertensive men. Fatigue was measured subjectively by the Borg rating scale and objectively by blood lactate concentrations. Resting and exercise heart rates were lower with metoprolol than with either dose of epanolol. Preexercise standing diastolic blood pressure was lowered by metoprolol, but there were no other treatment effects on blood pressure. Exercise-induced fatigue was not altered by any treatment, whether measured subjectively or objectively. These results do not support the hypothesis that partial agonist activity improves exercise tolerance in hypertensive patients treated with beta-adrenoceptor antagonists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637640
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  • 2
    Electronic Resource
    Electronic Resource
    Long-term amiodarone therapy raises serum cholesterol (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 477-480 
    Details
    ISSN: 1432-1041
    Keywords: Amiodarone ; cholesterol ; serum levels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Serum total cholesterol and triglyceride levels were measured in 12 patients before and 3, 6 and 9 months after treatment with amiodarone. In addition, we monitored serum T4, T3, reverse T3 and TSH levels. Amiodarone and its desethyl metabolite levels were measured on each occasion. Serum total cholesterol and T4 levels rose from 5.95 mmol/l, and 102.7 mmol/l respectively at baseline to 6.95 and 115.8 at 6 months and reverse T3 increased at 3, 6 and 9 months from baseline. Serum triglycerides did not change. No relationship existed between cholesterol, T4 and T3 and amiodarone (or its metabolite) levels nor between cholesterol and thyroid hormone levels. These data demonstrate that amiodarone therapy is associated with an elevation in serum cholesterol. This may have clinical implications in view of the current widespread use of the drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315226
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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