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  • 1
    Electronic Resource
    Electronic Resource
    The effect of aging on the positive chronotropic response to amitriptyline (1984)
    Springer
    Psychopharmacology 82 (1984), S. 256-257 
    Details
    ISSN: 1432-2072
    Keywords: Amitriptyline ; Antimuscarinic ; Catecholamines ; Positive chronotropy ; Aging ; Norepinephrine ; Angina ; Sinus heart rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Amitriptyline (AT) increases sinus heart rate (SHR) due to inhibition of the reuptake of norepinephrine in combination with an antimuscarinic blockade of cardiac vagal inhibition. After 150 mg/day AT for 28 days, the change in SHR was negatively correlated with age in 42 depressed patients who were 18–85 years of age. This finding is consistent with observations that the tachycardic response to antimuscarinics and catecholamines decreases with aging.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427785
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