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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 302 (1978), S. 87-90 
    ISSN: 1432-1912
    Keywords: Cats ; Cardiac glycosides ; Brain ; Distribution ; Side-effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The tissue/plasma ratio of β-methyl-digoxin for cardiac muscle in cats was about the same 24 h after a single dose of 30 μg/kg as after a loading dose of 30 μg/kg followed by 3 maintenance doses of 7.5 μg/kg at 24 h intervals. The ratio for the brain increased 2-fold during that time. After the i.v. injection of a toxic loading dose of 70 μg/kg β-methyl-digoxin or digoxin, maintenance doses of as little as 15 μg/kg at 48 h intervals sufficed to maintain the minimum plasma glycoside concentrations determined by RIA at about 3 ng/ml. There was no difference in the plasma concentrations or in the severity of intoxication produced by both glycosides. Cats vomited within 3 h after i.v. injection of 100 μg/kg β-methyl-digoxin, whereas a loading dose of 30 μg/kg followed by 3 injections of 7.5 μg/kg at 24 h intervals were well tolerated. The concentration of radioactivity in the brain 3 h after 100 μg/kg was less than 24 h after the last injection of 7.5 μg/kg in the experiments with repeated dosage. Cerebral side-effects such as vomiting, loss of appetite and weight were better correlated with the glycoside concentrations in the plasma than with those in the brain.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Plant and soil 53 (1979), S. 445-453 
    ISSN: 1573-5036
    Keywords: Alluvial soils ; Ammonium ; Amino acids ; Chernozem ; Clay minerals ; Electroultrafiltration ; EUF Nitrate ; Nmin ; N release ; N reserves
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The determination of N fractions in the soil by means of electro-ultrafiltration (EUF) is described. The results can be summarized as follows: 1) For aqueous soils suspension the direction of NH4 + and NO3 − migration in an electric field is determined by electrical charge and water flow. Therefore the filtrates obtained at both the cathode and anode can be mixed for subsequent analysis for NH4−N and NO3−N. In order to avoid N losses the volatile NH3 is recovered in 1N HCl solution. 2) Considerable amounts of NH4−N and NO3−N as well as low-molecular organic N compounds can be determined by EUF in soil samples taken from June to September. The readily available N is extracted by EUF at 20°C and 200 V, while determinations at 80°C and 400 V also give information on N release from reserves. 3) It was demonstrated with soils from long term N and K fertilizer experiments that the EUF−NO3 contents reflect the N accumulation in the soil due to N fertilization or plant residues. In clayrich soils the EUF−NH4 contents give information on the release of fixed NH4. Moreover EUF−NH4 also gives information on N from readily mineralizable organic compounds. The EUF procedure gives improved insight into the N dynamics of a site and this should serve as a basis for N-fertilizer recommendations.
    Type of Medium: Electronic Resource
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