ISSN:
1432-2072
Keywords:
Amphetamine sensitization
;
Pavlovian conditioning
;
Amphetamine-induced circling behavior
;
SCH 23390
;
Metoclopramide
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Circling behavior was measured in female rats treated with amphetamine (1.25 mg/kgd-amphetamine sulfate, IP) on 3 consecutive days. On days 4 and 5 saline was substituted for amphetamine. While the amphetamine-induced response was attenuated by both a D-1 (SCH 23390) and a D-2 (metoclopramide) antagonist, sensitization to amphetamine was attenuated by the D-1 antagonist only. In addition, expression of a placebo-like response observed on day 4 (characterized previously as a Pavlovian conditioned response) was attenuated by both the D-1 and D-2 antagonists without disrupting extinction of the response.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02244223
Permalink