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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 102 (1968), S. 297-304 
    ISSN: 1432-1076
    Keywords: Hepatitis ; Panmyelophthise ; Pancytopenie ; Anämie ; Agranulocytose ; Thrombocytopenie ; Chloramphenicol ; Hämorrhagische Diathese
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Seit 1955 wurden in der Weltliteratur 18 Fälle veröffentlicht, bei denen sich im Anschluß an eine infektiöse Hepatitis eine Panmyelophthise entwickelte. Während sich die Hepatitis besserte, ging die Panmyelophthise fast ausnahmslos innerhalb kurzer Frist letal aus. Der typische Verlauf der Erkrankung wird an Hand eines eigenen Falles bei einem vierjährigen Jungen beschrieben, im Zusammenhang mit den anderen werden Ätiologie und Pathogenese diskutiert. Als mögliche Ursachen stehen in Frage: 1. der Virusbefall hämatopoetischer Zellen, 2. medikamentöse Knochenmarkschädigung, 3. Stoffwechsel-Intoxikation, und 4. ein autoimmunologischer Prozeß.
    Notes: Summary Up to now there are 18 cases published in the world since 1955, in which several weeks following eruption of infectious hepatitis happened to develope a complicating panmyelophthisis. Whereas hepatitis is recovering, panmyelophthisis proved to be fatal within a short time almost without exception. The characteristic progress of the disease is described in the case of a boy aged 4 years, other cases are cited, etiology and pathogenesis discussed. The following causes are to be conceived of: virus infection of hematopoetic cells, lesions of bone marrow by remedies, metabolic intoxication and immunological disease.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: A concept has been suggested that the role of immunogen is to stimulate resting cells to enter a phase of the cell cycle in which the synthesis of immunoglobulin is obligatory. This process conceivably involves the initial union of cells with immunogen followed by a subsequent transition from resting to proliferating cell. Several aspects of an in vitro cellular transition have been investigated using cultured WIL2 lymphocytes which are shown to enter the G1 phase of the cell cycle upon release from rest. This transition is associated with phenotypic changes in the cells manifested by differences in density of individual cells and the amount and profile of polyribosomes. An increase in the rate of synthesis of total protein and specific immunoglobulin polypeptides accompanies the G0 to G1 transition. Agents useful in bacterial and other mammalian cell systems to probe translational versus transcriptional control mechanisms are active in these lymphocytes. This cellular model appears to offer unique opportunities to approach regulatory problems in cell biology because large numbers of synchronized cells are obtainable in which specific messenger-RNAs and their corresponding polypeptides can be isolated in relatively pure form.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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