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  • Anaerobic work capacity  (1)
  • BRCA1  (1)
  • Breast neoplasms  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Annals of oncology 10 (1999), S. 113-119 
    ISSN: 1569-8041
    Schlagwort(e): BRCA1 ; BRCA2 ; inherited susceptibility ; penetrance ; linkage mapping
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Background. Epidemiological studies have repeatedly shown that having a family history is a risk factor for female (and male) breast cancer. Some rare families have many (4 or more) cases of early onset breast cancer (some of which also include women with ovarian cancer) which are most clearly explained by an autosomal dominant gene with high penetrance. Design. Families with multiple cases of early onset breast (and/or ovarian cancer) have been studied using linkage analysis with the intention of finding the chromosomal region containing such genes. Results. Two predisposition genes, BRCA1 and BRCA2, have been mapped and cloned. Mutations in these genes confer increased risks of cancer, although the precise level of the increased risk is still unclear. The majority of families with four or more cases of breast cancer diagnosed under the age of 60 years are due to mutations in BRCA1 or BRCA2. Conclusions. The importance of these two genes to familial breast cancer and to breast cancer incidence overall is becoming clearer, the current information is reviewed. The findings can be immediately translated into clinical practice for these multiple case families. The identification of such families raises a number of other important clinical questions concerning patient management.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    European journal of applied physiology 71 (1995), S. 559-561 
    ISSN: 1439-6327
    Schlagwort(e): Critical power ; Anaerobic work capacity ; Methodology ; Electrically-braked ergometer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This study examined the effect of end-point cadence on the parameters of the work-time relationship determined for cycle ergometry. Eight male subjects completed four maximal tests on an electrically-braked cycle ergometer that regulated a constant power output independent of cadence. The power outputs imposed ranged between an average of 259 W and 403 W, whereas the corresponding durations ranged between 139 s and 1691 s. During each test subjects were required to maintain a cadence of 80–90 rpm. Accumulated time to end-point cadences of 70, 60 and 50 rpm were recorded. The four work-time determinations for each of three end-point cadences were used to determine linear relationships between work and time, yielding both a y-intercept, which represents anaerobic work capacity, and a slope, which is termed critical power (CP), for each end-point cadence. There was a significant increase in the y-intercept as end-point cadence decreased from 70 to 60 rpm (F[1,7]=36.7, p 〈 0.001) or 70 to 50 rpm (F[1,7]=80.1, p 〈 0.001), but not from 60 rpm to 50 rpm (F[1,7]=3.28, p 〉 0.05). In contrast, there was no effect of end-point cadence on CP (F[2,14]=1.89, p 〈 0.05). These results demonstrate that the end-point cadence selected to terminate tests only affects the y-intercept of the work-time relationship. To control for this effect, the cadence at which each test is terminated should be standardised if determination of anaerobic work capacity, as represented by the y-intercept, is required.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Cancer causes & control 5 (1994), S. 458-470 
    ISSN: 1573-7225
    Schlagwort(e): Breast neoplasms ; case-control studies ; familial risk ; genetics ; pedigree analysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Clinical observations suggest that breast cancer is occasionallyinherited as an autosomal dominant disease in families. Epidemiologic studies consistently have shown that a history of breast cancer in a first-degree relative increases a woman's risk of breast cancer when compared with the general population. The risk is similar if a mother or sister is affected and is increased further if both are affected. The difficulty with such an observation is that in itself it does not clarify the nature of the true underlying risk factors which could be genetic or due to the aggregation of environmental risk factors in families. Complex segregation analysis of breast cancer aggregation in families suggests that breast cancer susceptibility is due to an autosomal dominant inheritance of one or more rare genes in a few families in which carriers have a high probability of developing the disease perhaps as great as 100 percent. Close linkage of a breast-cancer-susceptibility gene (BRCA1), between markers of the chromosomal region 17q12-q21 on the long arm of chromosome 17, with breast cancer recently has been reported. Families linked to BRCA1 were more likely to have early onset of breast cancer or have breast and ovarian cancer in the family. It is likely that other genes play a role in the unlinked breastcancer families. Both the epidemiologic and genetic data suggest that breast cancer is a heterogeneous disease.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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