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  • Life and Medical Sciences  (3)
  • Anaerobic work capacity  (1)
  • Colorectal cancer  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Diseases of the colon & rectum 39 (1996), S. 739-743 
    ISSN: 1530-0358
    Schlagwort(e): Colorectal cancer ; Family history ; Hereditary nonpolyposis colorectal cancer ; Hereditary susceptibility
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Close relatives of patients with colorectal cancer are at an increased risk of developing a colorectal malignancy themselves. PURPOSE: A study was conducted to compare risks in relatives of patients diagnosed at different ages. METHODS: Family histories were taken from two cohorts of patients with colorectal cancer: Group A, a population group of 65 patients diagnosed at or under 45 (median, 42) years; Group B, 212 patients of all ages (median, 68 years) treated in a single surgeon's practice. RESULTS: Overall relative risk of colorectal cancer in first-degree relatives was 5.2 in Group A and 2.3 in Group B. There was familial clustering of colorectal cancers suggestive of hereditary nonpolyposis colorectal cancer in 13 (20 percent) families to Group A but to only 3 (1.5 percent) families in the second group. Cumulative incidence of colorectal cancer for relatives of the young cohort rose steeply from 40 years, reaching 5 percent at age 50 years and 10 percent at age 70 years. This contrasts with risk for relatives of older patients, in whom the shape of the curve resembles that of the overall population risk, reaching 5 percent at age 70 years and 10 percent at age 80 years. CONCLUSIONS: There appears to be a quantitative and qualitative increase in risk to relatives of patients diagnosed at a young age compared with those diagnosed later to life, at least part of which is likely to be the result of a hereditary susceptibility. Close relatives of early onset cases warrant more intensive endoscopic screening and at an earlier age than relatives of patients diagnosed at older ages.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    European journal of applied physiology 71 (1995), S. 559-561 
    ISSN: 1439-6327
    Schlagwort(e): Critical power ; Anaerobic work capacity ; Methodology ; Electrically-braked ergometer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This study examined the effect of end-point cadence on the parameters of the work-time relationship determined for cycle ergometry. Eight male subjects completed four maximal tests on an electrically-braked cycle ergometer that regulated a constant power output independent of cadence. The power outputs imposed ranged between an average of 259 W and 403 W, whereas the corresponding durations ranged between 139 s and 1691 s. During each test subjects were required to maintain a cadence of 80–90 rpm. Accumulated time to end-point cadences of 70, 60 and 50 rpm were recorded. The four work-time determinations for each of three end-point cadences were used to determine linear relationships between work and time, yielding both a y-intercept, which represents anaerobic work capacity, and a slope, which is termed critical power (CP), for each end-point cadence. There was a significant increase in the y-intercept as end-point cadence decreased from 70 to 60 rpm (F[1,7]=36.7, p 〈 0.001) or 70 to 50 rpm (F[1,7]=80.1, p 〈 0.001), but not from 60 rpm to 50 rpm (F[1,7]=3.28, p 〉 0.05). In contrast, there was no effect of end-point cadence on CP (F[2,14]=1.89, p 〈 0.05). These results demonstrate that the end-point cadence selected to terminate tests only affects the y-intercept of the work-time relationship. To control for this effect, the cadence at which each test is terminated should be standardised if determination of anaerobic work capacity, as represented by the y-intercept, is required.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 95 (1946), S. 313-319 
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Zusätzliches Material: 1 Tab.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 121 (1984), S. 63-77 
    ISSN: 0021-9541
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    ISSN: 0021-9541
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: Experiments will be described which demonstrate that the product of purified “Qβ-replicase” is fully competent to serve both as a template and as a program for the synthesis of complete virus particles. The use of mutant RNA has permitted the demonstration that nucleic acid is the instructive agent in the replication process and hence satisfies the definition of a self-duplicating entity. Methods have been devised to examine the product both physically and biologically with a minimum of manipulation and with complete recovery of product and input template. A detailed analysis of every interval of synthesis has thus become possible. These technical advances have permitted us to demonstrate the existence of a latent period prior to the appearance of the first new complete infectious RNA molecules. Further, this latent period is accompanied by an eclipse of the input templates as infectious agents. The use of electrophoretic separation on acrylamide gels has yielded a detailed account of both templates and early product during the latent period, with the consequent identification of the intermediate stages. The resulting data and their implications for the mechanism of RNA replication will be discussed.
    Zusätzliches Material: 29 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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