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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular 1202 (1993), S. 129-134 
    ISSN: 0167-4838
    Keywords: (Pancreas) ; Alpha amylase ; Amylase ; Enzyme modification ; Substrate specificity
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1530-0358
    Keywords: Obstetric injuries ; Rectovaginal fistula ; Fecal incontinence ; Incontinent anal sphincter ; Cloaca-like defect ; Anal/vaginal reconstruction ; Sphincteroplasty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: We categorized the various types of postobstetric injuries of the anorectum and vagina encountered in a five-year period. The operative procedures used to repair these injuries and the functional outcome after surgery were assessed. METHODS: Between 1986 and 1991, 52 patients were surgically treated for obstetric injuries of the anorectum and vagina; 48 patients were available for follow-up study. Four clinical injury types were identified: Type I, incontinent anal sphincter (11 patients); Type II, rectovaginal fistula (16 patients); Type III, rectovaginal fistula and incontinent anal sphincter (11 patients); and Type IV, cloaca-like defect (10 patients). The mean age of the patients was 30 years, the mean duration of symptoms before surgery was 13 months, and the mean follow-up period was 16 months. The major component of surgical repair for each injury type was: Type I, overlap repair of external anal sphincter; Type II, rectal mucosal advancement flap; Type III, overlap repair of external anal sphincter and rectal mucosal advancement flap; and Type IV, overlap repair of external anal sphincter, anterior levatorplasty, and anal and vaginal mucosal reconstruction. Fecal diversion was not performed in any patient. Specific questions were asked at the most recent follow-up assessment to determine results. RESULTS: Continence status postoperatively was classified as perfect, impaired, or poor; poor was defined as no improvement or worse. Postoperative continence (perfect, impaired, or poor) was, respectively: Type I (11 patients), 64 percent, 36 percent, and 0 percent; Type II (16 patients), 56 percent, 0 percent, and 44 percent; Type III (11 patients), 64 percent, 36 percent, and 0 percent; and Type IV (10 patients), 90 percent, 10 percent, and 0 percent. Vaginal discharge of stool was eliminated in all patients with a rectovaginal fistula. Subjectively, 92 percent of the patients had excellent or good results. Complications included wound hematoma (n=2), fecal impaction (n=2), urinary retention (n=1), and urinary tract infection (n=1). CONCLUSION: Patients with Type II injuries had the worst results (P 〈 0.001). These patients should be evaluated for anal incontinence before surgery to assess the need for a concomitant sphincteroplasty.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 69 (1996), S. 45-52 
    ISSN: 1432-1246
    Keywords: Key words Vibratory sensation ; Vibration exposure ; Threshold shift ; Temporary threshold shift ; Gripping force
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract ⋅Objective This study examines the effect of the force with which a vibrating handle is gripped on the temporary threshold shift of vibratory sensation (TTSv) induced by hand-arm vibration. ⋅  Methods Six healthy subjects gripped a handle vibrating with a 1/3 octave-band vibration, with a central frequency of 200 Hz and an intensity of 39.2 m/s2. Exposure was for 1 min and 10 min, respectively. Gripping forces for the 1-min exposure were 5 N, 10 N, 40 N and 80 N, respectively, with 0 N push-pull force. Gripping forces for the 10-min exposure were the same as for the 1-min exposure, but omitting 80 N. The vibratory sensation threshold at 125 Hz was measured before and after exposure of an exposed fingertip to vibration. The differences measured determine TTS v,t at time t. TTS v,t determines TTSv,0, that is, the temporary threshold shift of vibratory sensation immediately after exposure to vibration according to the estimate made on the basis of the preceding study. The same experimental conditions were repeated 3 times on different days in a soundproof and thermoregulated room. ⋅  Results Our findings show that TTSv increases significantly with increasing gripping force. We also determined the quantitative relationships between TTSv,0 and gripping force as described by the equation where k f and c f are constants and F is gripping force. ⋅  Conclusion This study revealed the importance of ergonomic design in reducing the force with which a vibrating handle is gripped to prevent an adverse effect of local vibration. The equation devised may help in the quantitative assessment of the effect of reduced gripping force.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1246
    Keywords: Human skin ; Vibratory sensation Vibration exposure ; Threshold shift ; Acute effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A new, self-recording, vibratory sensation meter measures temporary threshold shifts of vibratory sensation (TTSv) on a finger tip. After exposure to hand-transmitted vibration with exposure frequencies 63 Hz, 200 Hz and 500 Hz, and levels of acceleration 1 g, 2 g, 4 g and 8 g, fingertip measurements were obtained. Temporary threshold shift immediately after the vibratory exposure (TTSVv,0) was estimated for each exposure from the regression analysis by approximation of an exponential function. Time constant (tc) was also estimated at the same time by the analysis. The coefficients of determination were large. Thus, the fit of the exponential function is very good for each exposure. The tc corresponds to the recovering velocity of the temporary shift and implies the half-life period of TTSv. These parameters enable us to examine more generally the relationships of TTSv to the characteristics of exposure vibration, subject and other conditions. On this basis, the estimated TTSv,0 and tc were used to examine the dependency of TTSv on the characteristics of the exposure vibration and the subject. The most effective frequency under the level of 4 g is thought to be between 200 Hz and 500 Hz. TTSv,0 of each subject proportionally increased with power of acceleration. The coefficient of determination on regression analysis was large. This result enables us to estimate TTSv,0 at an arbitrary level of acceleration by use of a regression equation derived from experimental data.
    Type of Medium: Electronic Resource
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