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Digitale Medien

Cytokeratin polypeptide expression in a cloacogenic carcinoma and in the normal anal canal epithelium (1991)

Levy, Rivka ; Czernobilsky, Bernard ; Geiger, Benjamin

Springer

Virchows Archiv 418 (1991), S. 447-455

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Details

ISSN: 1432-2307

Schlagwort(e): Cloacogenic carcinoma ; Anal ; Canal ; Cytokeratins ; Immunohistochemistry

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The aim of the present study was to explore the origin of cloacogenic carcinoma in the anal canal by immunohistochemical methods. We compared cytokeratin polypeptide expression of a cloacogenic carcinoma to normal anal epithelia, to anal squamous cell carcinoma and to basal and squamous cell carcinoma of the skin, using a battery of monoclonal anti-cytokeratin, polypeptide-specific antibodies. Our results indicate that cloacogenic carcinoma expresses cytokeratin polypeptides similar to those of the basal layer of anal squamous epithelium, of the anal transitional zone epithelium and of a layer of basal cells in the anal glands. Thus we concluded that each of the above cell types may be the cell of origin of cloacogenic carcinoma.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01605932

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