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Digitale Medien

Potentiation of the efficacy of murine L1210 leukemia vaccine by a novel immunostimulator 7-thia-8-oxoguanosine: Increased survival after immunization with vaccine plus 7-thia-8-oxoguanosine (1991)

Sharma, Brahma S. ; Balazs, Louisa ; Jin, Ai ; [weitere]

Springer

Cancer immunology immunotherapy 33 (1991), S. 109-114

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ISSN: 1432-0851

Schlagwort(e): Vaccine ; Immunostimulator ; L1210 leukemia

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary We have investigated the ability of a novel immunopotentiator, 7-thia-8-oxoguanosine (7T8OG) to increase the efficacy of a weakly immunogenic murine L1210 leukemia vaccine. The vaccine was prepared by irradiating L1210 leukemia cells in a cesium source with a total of 6000-R dose. DBA/2 mice were treated with 150 mg/kg 7T8OG and/or with vaccine consisting of 107 irradiated cells. In combination therapy, mice first received the vaccine and then were injected with 75 mg/kg 7T8OG 2 h and 4 h after vaccination. One week after the last treatment all mice were inoculated with 104 live leukemia cells intraperitoneally. Control, untreated mice (n = 66) injected with 104 live leukemia cells had a mean survival time ± standard error of 10.5±0.2 days. Treating mice (n = 66) with one, two or three doses of 7T8OG administered i.p. 1 week apart did not increase survival (mean survival time = 10.7 days). Mice immunized with one, two or three doses of vaccine had 14.5±1.1, 45.4±6.2 and 68.3±10.6 days mean survival, respectively. 7T8OG-stimulated vaccination increased the survival dramatically. The best survival was noted when the mice were treated with 2× (vaccine + 7T8OG). Immunization of mice (n = 30) with this treatment regimen increased the mean survival to 156±10.0 days. Over 90% of mice that were treated this way had a cumulative survival time greater than 160 days. In contrast, only 12% of the mice immunized twice with the leukemia vaccine alone survived over 160 days. These results suggest a rationale for the use of this immuno-potentiator with various vaccines for a more effective immunization.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01742538

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Digitale Medien

Field ionization mass spectrometry - I. NucleosidesThis paper is also Part IX in the series ‘Structural Biochemistry’. For Part VIII see g. R. Pettit and S. K. Gupta, J. Chem. Soc. (C), 1208 (1968). (1969)

Brown, Peter ; Pettit, George R. ; Robins, Roland K.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 2 (1969), S. 521-531

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ISSN: 0030-493X

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The field ionization mass spectra of a series of nucleosides are reported, and compared with spectra obtained by conventional electron-impact ionization. The latter are complex, with structurally significant molecular ion and sugar cleavage peaks often of low intensity or completely absent. In contrast, the field ion spectra are extremely simple, with all except guanosine (highest mass peak [M - 18]) showing intense molecular ion peaks, and the characteristic sugar (S) and base (B + H) cleavage products as the only other important fragments.

Zusätzliches Material: 10 Ill.