ISSN:
0749-1581
Keywords:
Aminoglycosides
;
Phosphatidylinositol
;
15N NMR
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The 15N NMR spectra of eight aminoglycosides were interpreted. The effect of mixing 20 mol.% of various aminoglycosides with phosphatidylinositol in aqueous dispersion was studied by 15N NMR, and correlations were found between the degree of interaction of the aminoglycoside for phosphatidylinositol and the calculated energy of interaction of the antibiotic with the negatively charged phospholipid and the inhibitory potency of the drug towards lysosomal phospholipase A1, a critical parameter in the nephrotoxic potential of aminoglycosides.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260300104
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