ISSN:
0749-1581
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Methylmercuration of cytidine-3′-monophosphate is shown to occur at the N-3 site, resulting in a substantial upfield shift in the 15N resonance of this nitrogen. For guanosine-5′-monophosphate the 15N NMR data show N-1 to be the site of complexation of CH3Hg+ at pH 8. The large downfield shift observed for N-1 as a result of this binding is explained in terms of a concomitant deprotonation phenomenon. Changes in 13C NMR chemical shifts on methylmercuration are less pronounced, but consistent with these binding sites.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260240604
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