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  • Analytical Chemistry and Spectroscopy  (4)
  • Moclobemide  (3)
  • 1
    Digitale Medien
    Digitale Medien
    Initial monoamine oxidase-A inhibition by moclobemide does not predict the therapeutic response in patients with major depression A double blind, randomized study (1996)
    Springer
    Psychopharmacology 127 (1996), S. 370-376 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Key words Monoamine oxidase-A inhibition ; Treatment outcome ; DHPG ; L-dopa ; DOPAC ; HVA ; 5-HIAA ; Moclobemide ; Depressive patients
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract It is generally accepted that the clinical efficacy of monoamine oxidase inhibitors (MAOI) is related to inhibition of this enzyme. In order to evaluate the predictive ability of monoamine oxidase-A inhibition for therapeutic efficacy, the start of treatment effects of moclobemide, a selective, reversible monoamine oxidase-A inhibitor, on plasma concentrations of monoamines and monoamine metabolites were determined. The plasma levels of 3,4-dihydroxyphenylglycol (DHPG, deaminated metabolite of noradrenaline), 5-hydroxyindoleacetic acid (5-HIAA, deaminated metabolite of serotonin), 3,4-dihydroxyphenylacetic acid and homovanillic acid (DOPAC and HVA, deaminated metabolites of dopamine), L-dihydroxyphenylalanine (L-dopa) and noradrenaline were investigated and related to treatment outcome. This was a randomized double blind parallel group study in 47 patients with criteria of major depression according to DSM III R. Moclobemide 300 mg/day, 450 mg/day or 600 mg/day was administered continuously for 6 weeks. Plasma concentrations of monoamine metabolites and monoamines were determined just before treatment by moclobemide, 4 h after the first dose, 24 h after the first dose, before the first dose on day 7, and 4 h after the first dose on day 7. Each moclobemide dose improved depression as measured by MADRS (Montgomery-Asberg Depression Rating scale) but there was no difference between the three doses. Moclobemide dose-dependently reduced plasma concentration of DHPG, L-dopa and HVA. No dose-dependent treatment effect was observed for plasma 5-HIAA, noradrenaline and DOPAC. The clinical outcome as defined by the final MADRS score was not related to any start of treatment changes in plasma monoamine metabolites reflecting inhibition of MAO-A. It is concluded that monoamine oxidase-A inhibition at the beginning of the treatment does not predict clinical outcome.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002130050100
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  • 2
    Digitale Medien
    Digitale Medien
    Comparative investigation of the effect of moclobemide and toloxatone on monoamine oxidase activity and psychometric performance in healthy subjects (1992)
    Springer
    Psychopharmacology 106 (1992), S. S68 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Moclobemide ; Toloxatone ; Monoamine oxidase-A ; Psychometric performance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effects of moclobemide and toloxatone, two reversible monoamine oxidase-A inhibitors, on biochemical parameters that reflect monoamine metabolism and on psychomotor performance parameters were investigated in a study in 12 healthy volunteers. Treatments were given double-blind in a randomised, placebo-controlled cross-over design, with 1 week wash-out between the treatments. Drugs were given thrice daily in the following doses: moclobemide 150-150-150 mg and toloxatone 400-200-400 mg. All assessments were performed on day 8 under standardized conditions. There was no difference with regard to adverse events between moclobemide and toloxatone: both drugs induced a slight decrease in both supine and standing heart rate. Judged on the basis of the area under the curve, the two MAO-inhibitors reduced the plasma levels of DHPG and HVA, with more pronounced effects for moclobemide than for toloxatone. After moclobemide MAO-A inhibition was almost constant over 24 h, whereas the effect of toloxatone was short lasting after each dose. The same differences were reflected in plasma 5-HIAA concentrations and urinary excretion of 3-methoxytyramine and normetanephine. Neither of the compounds tested had any influence on the memory, vigilance, mood, or sleeping habits of the subjects.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02246239
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  • 3
    Digitale Medien
    Digitale Medien
    Evaluation and comparison of the interaction between alcohol and moclobemide or clomipramine in healthy subjects (1990)
    Springer
    Psychopharmacology 101 (1990), S. 40-45 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Clomipramine ; Moclobemide ; Interaction with alcohol ; Psychometric performance ; Body sway ; Anticholinergic effects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The interaction of clomipramine and moclobemide with alcohol was compared in a double blind parallel groups study in 24 healthy volunteers. Moclobemide was given at the highest recommended therapeutic dose (200 mg t.i.d.) and clomipramine in a subtherapeutic dose (25 mg b.i.d.) because of its poor tolerance in healthy subjects. Psychometric evaluations were performed during a placebo run-in phase; after a 5-day treatment period; assessments were made before, and again 1 h and 4 h after alcohol ingestion. Alcohol doses were pre-determined for each subject in order to produce a blood alcohol concentration of 0.6 g/l 1 h after alcohol intake and this individual alcohol dose was given on test days. The day before alcohol intake tests for autonomic functions were made to assess the anticholinergic effects of the drugs. Alcohol significantly increased body sway, decreased critical flicker fusion frequency, prolonged choice reaction time, impaired copying skills, impaired memory and increased the subjective feelings of satisfaction and tension. Drugs increased the effect of alcohol on body sway and this was essentially due to clomipramine. Clomipramine both without and with alcohol increased body sway, prolonged choice reaction time more than did moclobemide. Clomipramine seemed to diminish alcohol-induced memory impairment in one of the memory tests used. Subjects taking clomipramine had significantly more adverse effects after alcohol ingestion than did subjects of the moclobemide group. In contrast to moclobemide, clomipramine produced a moderate but significant drop in standing systolic blood pressure and a clear inhibition of salivary excretion. It may be concluded that no important psychometric differences occurred between moclobemide and clomipramine with respect to their interaction with alcohol but moclobemide did not show anticholinergic properties and produced fewer adverse effects than clomipramine in interaction with alcohol.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02245787
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  • 4
    Digitale Medien
    Digitale Medien
    Carbon-13 NMR investigation of 2,5-diaryl-1,4-dithiins (1979)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 12 (1979), S. 691-695 
    Details
    ISSN: 0030-4921
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The 13C NMR spectra of eight 2,5-diaryl-1,4-dithiins were recorded and signals were assigned. A linear correlation was observed between the electronegativity of the substituent groups on C-10,10′ and the chemical shifts of C-10,10′ after applying corrections for the magnetic anisotropic effect of the substituents. A Hammett correlation was found between the 13C chemical shifts of C-3,6 and C-7,7′ and the σp+ parameter associated with the substituents on C-10,10′. Extended electronic interaction between the π system of the aryl group and the π system of the dithiin ring was suggested by the observance of an alternating behavior in the magnitude of the substituent effects on the 13C shifts of C-2,5 and C-3,6. An alternating effect was also noted in the magnitude of the long-range 13C—F coupling constants for these same carbon signals in 2,5-(10,10′-difluoro)diphenyl-1,4-dithiin.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/mrc.1270121209
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  • 5
    Digitale Medien
    Digitale Medien
    Mass spectrometry of five classes of trityl compounds-loss of 12C from (C6H5)313CH (1969)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1969), S. 447-466 
    Details
    ISSN: 0030-493X
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The mass spectra of 25 triphenylmethyl (trityl) substituted compounds have been recorded. The trityl cation m/e 243 appears as a peak of major intensity for all classes of compounds examined; these contained trityl-carbon, trityl-nitrogen, trityl-oxygen or trityl-sulfur bonds. Fragmentation of the non-trityl portion of the molecules produced simple ions whose origin was predictable or of low intensity. A mechanism for the decay of the trityl cation is presented which is based upon retention of the α-carbon. Supporting evidence was afforded by mass spectral analysis of (C6H5)313CH in which all fragments from the trityl cation appear to retain nearly all of the 13C.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/oms.1210020503
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  • 6
    Digitale Medien
    Digitale Medien
    Synthesis and 1H, 13C and 31P NMR studies of 2,10-dichloro-6-aryloxy-12H-dibenzo [d,g] [1,3,2]-dioxaphosphocin 6-oxides (1991)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 29 (1991), S. 1140-1146 
    Details
    ISSN: 0749-1581
    Schlagwort(e): 1H, 13C and 31P NMR shifts ; 2,10-Dichloro-6-aryloxy-12H-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxides ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The spectral analyses and syntheses of several novel 2,10-dichloro-6-aryloxy/alkyl-12H-dibenzo [d,g] [1,3,2] dioxaphosphocin 6-oxides have been achieved. Long-range coupling [5J(H,P) = 2.4 Hz] was observed between phosphorus and the bridged methylene protons. Based upon NMR data, a tub-like conformation is proposed for the central eight-membered dioxaphosphocin ring. Long-range 2J(P,O,C) and 3J(P,O,C,C) couplins were determined, as were the 31P chemical shifts for sixteen members of these new heterocycles. A variable-temperature study of one member suggested the presence of a tub form as a reasonable candidate for one major conformer but the presence of other forms was also implied.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/mrc.1260291111
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  • 7
    Digitale Medien
    Digitale Medien
    Selenium-77 NMR spectral analysis of selected substituted selenanes, selenanones and 3-selena-7-azabicyclo[3.3.1]nonanes and derivatives (1986)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 24 (1986), S. 947-950 
    Details
    ISSN: 0749-1581
    Schlagwort(e): 77Se NMR ; Selenanes ; Selenanones ; 3-selena-7-azabicyclo[3.3.1]nonanes ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: A series of selenanes and selenanones have been examined using 77Se NMR analysis. Sharp resonances were found in all cases whether recorded at 47.7, 51.4 or 57.22 MHz or in DCCI3 or DMSO-d6. Diphenyl diselenide was used as the external reference, but all resonances were subsequently referred to dimethyl selenide (0°C, O ppm). It was observed that in the selenanone family any substituent at the α-, β- or γ-positions exerted a significant effect on the 77Se resonances. The same was true in the selenanes. Moreover, the presence of a chair-chair or chair-boat form in certain 3-selena-7-azabicyclo[3.3.1]nonan-9-ones and related 3-selena-7-azabicyclo[3.3.1]nonanes (and hydroperchlorates) induced remarkable differences in 77Se shifts. Some general observations and conclusions are delineated in terms of the influence of various groups on the 77Se resonances in these cyclic systems.
    Zusätzliches Material: 2 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/mrc.1260241104
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