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  • Analytical Chemistry and Spectroscopy  (1)
  • T lymphocytes  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 40 (1995), S. 1744-1749 
    ISSN: 1573-2568
    Keywords: IL-7 ; IL-9 ; IL-12 ; intraepithelial lymphocytes ; lamina propria lymphocytes ; T lymphocytes ; intestinal lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Human intestinal lymphocytes, particularly intraepithelial lymphocytes, proliferate minimally to some agents, like mitogens and stimuli of the CD3 pathway. Thisin vitro finding may be due, in part, to a loss of factors foundin vivo. Three T-cell growth factors, IL-7, IL-9, and IL-12, were tested for their ability to stimulate the proliferation of intestinal lymphocytes. Both intraepithelial lymphocytes and lamina propria lymphocytes proliferated more vigorously to IL-7 than to IL-9 or IL-12, and only IL-7 increased stimulation through the CD3 pathway. The IL-7-induced response was IL-2-dependent: IL-2 receptors appeared on both intestinal lymphocyte types, and antibody to the IL-2 receptor blocked IL-7-induced proliferation. Both CD4+ and CD8+ T-cell subsets responded to this cytokine as shown by phenotype-depletion experiments and constancy in the CD4/CD8 ratios after culture with IL-7. In addition, the T-cell receptor αβ and γδ subsets responded equally well to IL-7. This newly described selective proliferative response of intestinal lymphocytes to IL-7, but not to IL-9 or IL-12, requires no preactivation and may enhance, growthin vivo.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 18 (1989), S. 57-63 
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Because of the structural information it provides, mass spectrometry has gained widespread acceptance as the preferred analytical technique for drug residue confirmatory procedures. For the confirmation of the polyether ionophore antibiotic, maduramicin α, in chicken fat, the techniques of desorption chemical ionization (DCI), thermospray liquid chromatography/mass spectrometry (TSP LC/MS), and thermospray liquid chromatography/tandem mass spectrometry (TSP LC/MS/MS) were investigated as potential approaches. Sample clean-up was found to be totally inadequate for DCI and only marginally acceptable for TSP LC/MS. Only TSP LC/MS/MS adequately resolved the analyte from the tissue coextractives and generated satisfactorily reproducible mass spectrometric data for a confirmatory method. The techniques developed here should be applicable to other commonly used polyether ionophores.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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