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  • 1
    Electronic Resource
    Electronic Resource
    Electrospray mass spectrometric characterization of fluoroquinolone antibiotics: Norfloxacin, enoxacin, ciprofloxacin and ofloxacin (1995)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 9 (1995), S. 1038-1043 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: We report the electrospray (ESI) mass spectra of four fluoroquinolones, enoxacin, norfloxacin, ofloxacin and ciprofloxacin, a group of highly potent antibiotics that have not been previously characterized by this ionization technique. At low sampling cone voltage settings, 50 and 100 V, the electrospray mass spectra contained primarily molecular adduct ions. At a sampling cone voltage setting of 150 V, collisionally activated dissociation mass spectra containing structurally significant product ions were produced and accurately mass measured at a magnetic sector resolution of 3000. Gradient separation and characterization of these compounds was demonstrated by analysis using packed capillary column liquid chromatography with UV and ESI-MS detection. UV detection limits in the 1 to 2 ng range ((signal-to-noise ratio S/N) = 10:1) were estimated and interpretable mass spectra with S/N ratios in excess of 100:1 were observed for 1.5 ng of analyte during electrospray mass spectrometric analysis.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290091114
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  • 2
    Electronic Resource
    Electronic Resource
    The application of capillary electrophoresis/mass spectrometry using negative-ion electrospray ionization to areas of importance in the textile industry (1994)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 8 (1994), S. 179-182 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The feasibility of using capillary electrophoresis/mass Spectrometry, with negative-ion electrospray ionization, for applications of relevance to the dyeing and textile industries has been shown. Structurally similar examples of solubilized vat dyes of different halogen content have been separated and identified with a view to investigating the photodegradation processes which occur when the dyes are subjected to UV light. Separations of the various species formed when a mordant dye is chrome treated are also presented, indicating the ability to study complex formation arising from the different chrome dyeing methods.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290080211
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A high resolution gas chromatographic/mass spectrometric method for the determination of N-0923 in human and monkey plasma (1993)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 7 (1993), S. 1145-1149 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: A method that combines gas chromatography and mass spectrometry (GC/MS) for the determination of N-0923 in human and monkey plasma is detailed. This novel drug holds promise for the treatment of Parkinson's disease. Clinical use of N-0923 will result both in low peak plasma concentrations and in a short half-life; consequently, a highly sensitive method will be required. Previous methods using high-performance liquid chromatography with electrochemical detection have given reliable data in high dose studies in animals to 0.3-1.0 ng/mL in plasma but are not considered adequate for studies at clinical levels in humans. The data in this paper will show that GC/MS can offer a new direction in the determination of N-0923 in human and monkey samples, with reliable data to 25 pg/mL in plasma. This method is presented as a novel approach to the determination of N-0923, and as a starting point for further development.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290071218
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    NMR spectra of carotenoporphyrins. Computer-assisted conformational analysis (1984)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 22 (1984), S. 39-46 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A computer-assisted method of conformational analysis for porphyrin molecules bearing flexible side-chains has been developed. The method utilizes the ring current-induced chemical shift changes of the side-chain protons which arise from the porphyrin macrocycle and any attached aryl rings. The treatment has been applied to a series of carotenoporphyrin molecules, which are important as models for a variety of photophysical processes in biological systems. Chemical shift data of sufficient accuracy for the conformational analysis were obtained from 500 MHz NMR experiments. The conformations of the carotenoporphyrins varied from extended ones with the carotenoid well away from the porphyrin ring to tightly folded species, depending on molecular constitution. The analytical method can be extended to other porphyrin-based systems.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270220109
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    NMR spectral studies of quinoline derivatives. Long range 13C—1H coupling constants in methylquinoline derivatives (1976)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 8 (1976), S. 147-150 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Long range 13C—1H coupling constants are reported for a number of methylquinoline derivatives. The results have been compared with those observed in the pyridine series and correlated with 1H—1H coupling constants.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270080309
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Capillary column isobutane chemical ionization mass spectrometry of mustard and related compounds (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 553-564 
    Details
    ISSN: 0887-6134
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Capillary column isobutane chemical ionization was found to be an excellent method for the mass spectral characterization of mustard, other sulfur vesicants and related compounds. Interpretation of [M + H]+ and fragmentation ion information afforded by this technique enabled the identification of many previously unreported mustard impurities. The developed methodology was applied to the analysis of an Iran/Iraq soil sample suspected to have been contaminated with mustard. Mustard and 17 other mustard related impurities were identified and characterized in this sample under electron impact and isobutane chemical ionization conditions.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200151008
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  • 7
    Electronic Resource
    Electronic Resource
    Capillary column ammonia chemical ionization mass spectrometry of organophosphorus chemical warfare agents and simulants (1986)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 13 (1986), S. 231-236 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Capillary column ammonia chemical ionization mass spectrometry was investigated as a technique for the characterization of a number of organophosphorus chemical warfare agents and simulants, since electron impact ionization provides little or no molecular ion information for these compounds. The effects of source temperature, source pressure, electron energy and electron emission were investigated in order to optimize ammonia chemical ionization conditions. Source temperature was found to have a dramatic effect on the chemical ionization mass spectra acquired. Abundant [M + NH4]+ and/or [M + H]+ quasimolecular ions were usually observed at lower source temperatures for the selected compounds under positive ion chemical ionization conditions, along with a number of characteristic fragmentation ions. Full-scan mass spectra were obtained for 1--2 ng of analyte during the capillary column ammonia chemical ionization operation. The sensitivity, molecular ion information afforded and lack of background interference ions associated with this technique make it a good candidate for the confirmation of organophosphorus chemical warfare agents and simulants.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200130505
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Optimization of GC detector parameters using electronic pressure control (1992)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 15 (1992), S. 615-619 
    Details
    ISSN: 0935-6304
    Keywords: Capillary GC ; Splitless injection ; Electronic pressure control (EPC) ; Nitrogen - phosphorus detector (NPD) ; Flame photometric detector (FPD) ; Flame ionization detector (FID) ; Programmable cool on-column injection ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: HP 5890 Series II Gas Chromatographs are equipped with prototype hardware enabling electronic pressure programming of all detector and carrier gases. A method of using electronic pressure control (EPC) to optimize detector performance (sensitivity, selectivity, and baseline stability) is demonstrated. With EPC, sample introduction, column separation, and detector performance can be optimized simultaneously without the classical trade-offs in performance. An example is also presented of the use of a new automated system which enables cool on-column injection into 250 or 320 μm columns without the need for a retention gap.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240150912
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  • 9
    Electronic Resource
    Electronic Resource
    Simulated distillation of petroleum and its products by gas and supercritical fluid chromatography: A review (1994)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 17 (1994), S. 203-211 
    Details
    ISSN: 0935-6304
    Keywords: Simulated distillation ; Boiling point distribution ; Element-specific detectors ; Carbon number distribution ; Petroleum ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Information about the boiling point distribution of petroleum and its products is obtained either by actual distillation, or by analyses designed to simulate the distillation process. These analytical techniques are called simulated distillations. Simulated distillations are most often performed by gas or supercritical fluid chromatography. This paper reviews the use of gas and supercritical fluid chromatography for simulated distillation, and the development of element-specific detection coupled with these analyses.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240170404
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  • 10
    Electronic Resource
    Electronic Resource
    Complete Separation of Isomeric Penta- and Hexachloronaphthalenes by Capillary Gas Chromatography (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 639-643 
    Details
    ISSN: 0935-6304
    Keywords: Cyclodextrin ; Halowax ; hexachloronaphthalene ; PCN ; polychlorinated naphthalenes ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---No abstract
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
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