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  • 1
    ISSN: 1075-4261
    Keywords: doxorubicin ; intercalation ; resonance Raman ; SERRS ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: The interactions of doxorubicin and its derivatives, hydroxyrubicin and adriamycinone, with DNA were studied by resonance Raman (RR) and surface-enhanced resonance Raman scattering (SERRS) spectroscopy. The π-π interaction between the chromophore of the drug and DNA base pairs has been shown to downshift the skeletal stretching mode ∼ 1440 cm-1 by 8, 5, and 4 cm-1 for doxorubicin, hydroxyrubicin, and adriamycinone, respectively. The additional effects of intercalation with DNA on the RR and SERRS spectra for hydroxyrubicin are similar to those for doxorubicin. However, different effects are observed for adriamycinone. These results indicate that the sugar moiety is necessary to maintain the maximum van der Waals contact between the chromophore and the DNA base pairs and that the amine group in the amino sugar is more favored than the hydroxyl group. © 1997 John Wiley & Sons, Inc. Biospectroscopy 3: 307-316, 1997
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 20 (1989), S. 645-650 
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Carboxylate and guanidinium groups of amino acids have been studied by ultraviolet resonance Raman (UVRR) spectroscopy. On near-resonant excitation (192 nm) into the allowed π-π* transition of the carboxylate chromophore, the vibrational spectrum of aspartate displays only one band originating from the COO- symmetric stretching mode, consistent with an A-term enhancement mechanism. The UVRR spectra of the guanidinium ion reveals a complex vibrational pattern, and the bands have been assigned with the aid of a normal coordinate analysis. UV enhancement is observed for both asymmetric (E′) and totally symmetric (A1′) modes, and also for the overtone of the out-of-plane CN3 bending mode, Γ(A2″). The E′ enhancement is suggested to reflect Jahn - Teller splitting in the first allowed electronic transition A2″ ← E″, whereas the 2Γ(A2″) enhancement requires a lowering of the force constant for out-of-plane bending in the excited state, consistent with its expected tendency toward pyramidalization. Similar enhancement patterns are seen in the UVRR spectra of the guanidinium chromophore in methylguanidinium and arginine, which show, in addition, splittings and intensity redistribution due to the substituents. The excitation profiles of guanidinium and arginine reveal a complex structure that may arise from an excited-state Jahn - Teller effect. The Raman enhancements are too low to permit detection of guanidinium or carboxylate in the UVRR spectra of proteins, even at wavelengths as low as 192 nm.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 16 (1985), S. 432-437 
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Two novel devices for difference Raman spectroscopy are described. In one, an NMR tube is fltted with a PTFE divider to permit difference spectroscopy via the convenient spinning tube backscattering arrangement. The other device is a tuning fork, equipped with a pair of sample cups, attached to a cold finger, to permit acquisition of difference spectra on small samples of frozen solutions. This provides a particularly convenient method for low-temperature difference spectroscopy.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A simple, small-volume, low-temperature bulk electrolysis Raman spectroelectrochemical cell has been constructed which allows collection of resonance Raman (RR) spectra in situ from a rapidly stirred electrolysed solution. The cell has been used to obtain the first RR spectrum of electrochemically generated ferryl tetramesitylporphyrin (TMPFeIV =O), formed at -40°C by electrooxidation of TMPFeIIIOH in CH2CI2 solution.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 19 (1988), S. 65-69 
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A simple, small-volume, anaerobic spectroelectrochemical cell for surface-enhanced Raman spectroscopy (SERS) has been developed which incorporates a large surface area rotating cylindrical electrode design. The cell has been demonstrated to be effective in minimizing photoreduction of light-sensitive MnIII protoporphyrin.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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