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  • 1
    Electronic Resource
    Electronic Resource
    DNA profile and tumour progression in patients with superfical bladder tumours (1982)
    Springer
    Urological research 10 (1982), S. 13-18 
    Details
    ISSN: 1434-0879
    Keywords: DNA profile ; Tumour progression ; Superficial bladder tumours
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 229 patients with Grade 1–2 tumours (WHO), all category Ta or T1 (UICC) and surgically treated, were followed clinically and by flowcytofluorometric DNA-analysis (FCM). The tumours were characterised by their DNA profile. 175 cases were found to be diploid and fiftyfour cases showed aneuploidy. The mean follow-up time with continous FCM analysis was 2.6 years. During this period 19 patients showed tumour progression and 11 of these patients died. No progressive cases were found among 175 patients with repeatedly diploid DNA patterns. Thus tumour progression was exclusively linked to an aneuploid DNA pattern. In these case the degree of ploidy determined the frequency of progression: while 50% of the cases with triploid — hypotetraploid DNA pattern showed progression, only 10% of tumours with a tetraploid amount of DNA were found to be progressive. The degree of ploidy in 33 cases with recurrent aneuploid tumours was in general found to be constant. A fairly high degree of consistency was also found in the number of cells in S-phase, expressing proliferative properties. This indicates that superficial bladder tumours can be well characterised by their DNA profiles, that is the degree of ploidy and the proliferation pattern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256518
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Quantitative flow-microfluorometric analysis of the DNA in cells from neoplasms of the urinary bladder: Correlation of aneuploidy with histological grading and the cytological findings (1978)
    Springer
    Urological research 6 (1978), S. 201-205 
    Details
    ISSN: 1434-0879
    Keywords: DNA-analysis ; Bladder neoplasms ; Malignancy grading ; Aneuploidy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The total DNA content in single cells from bladder washingtons of patients with tumours in the bladder has been analysed by means of a rapid-flow cytofluorometer. The frequency of occurrence of aneuploid cell populations has been related to the cytological findings and the histological grading according to Bergkvist et al. The frequency of occurrence of aneuploid cell populations in 228 patients increased from 7% for tumours of grades 0 and 1 to 79% for grade III tumours. In cell material cytologically classed as benign the frequency of occurrence was 8% increasing to 96% for poorly differentiated carcinomas. In patients with tumours of histological grade II, subdivided into one group with minor atypical features with no invasion and one with major deviation from the normal cell picture and suspected or manifest invasion, the frequencies of occurrence of aneuploidy were 9% and 68% respectively. The degree of aneuploidy has been determined by comparison of the position of the DNA values in relation to the normal DNA values. In 54 irradiated patients with persistent or recurrent tumours the position of the aneuploid cell lines changed in the diploid direction in comparison with that for 65 non-irradiated patients for the majority of which the aneuploid cell lines were in the tritetraploid region. The biological significance of the different degrees of aneuploidy is as yet unknown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262618
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Aneuploid DNA pattern in human pituitary adenomas (1981)
    Springer
    European archives of oto-rhino-laryngology and head & neck 230 (1981), S. 1-4 
    Details
    ISSN: 1434-4726
    Keywords: Pituitary tumours ; DNA ; Histopathology ; Aneuploidy ; Hormone secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The DNA contents of 29 histologically and ultrastructurally benign pituitary tumours were analyzed with flow-cytofluorometry. — Cytogenetic malignancy, i.e., aneuploidy, was found in 12 cases, independent of endocrinological type of tumour. In 17 cases a diploid DNA content occurred. In aneuploid tumours varying percentage of cells in S-phase was found indicating different growth patterns. Aneuploid DNA pattern was often found in young patients with a short case history. Our findings indicate that analysis of cellular DNA content may reflect the biological properties of pituitary tumours, independent of morphologic characteristics and type of hormone secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00665373
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    Paper (German National Licenses)
    Fulltext
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