ISSN:
1432-2013
Keywords:
Renin
;
Angiotensin
;
Thirst
;
Hypovolemia
;
Polyethleneglycol
;
Saralasin
;
Captopril
;
Enalapril
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The role of the renin-angiotensin system as a mediator of water intake, induced by hypovolemia after polyethylene glycol (PEG) injection, was investigated. Blockade of angiotensin I converting enzyme and of angiotensin receptors was used as a pharmacological tool. A significant reduction of water intake was observed when angiotensin 1 converting enzyme was inhibited by captopril and enalapril. In PEG-treated rats with blockade of angiotensin I converting enzyme, hypertonic saline injection continued to elicit substantial drinking. Normalization of low blood pressure by vasopressin infusions in PEG and captopril treated rats did not interfere with the antidipsogenic effectiveness of converting enzyme blockade. The angiotensin II receptor antagonist, saralasin, also reduced PEG-induced drinking although less effectively than converting enzyme inhibitors. We conclude that water intake due to isotonic depletion of the extracellular fluid compartment may depend on the activity of the renin-angiotensin system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00583757
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