ISSN:
1432-5233
Keywords:
Angiotensin converting enzyme inhibition
;
Microalbuminuria
;
Renal haemodynamics
;
Type 1 diabetes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The renal effects of intravenous injection of 40 mg enalapril were investigated in 16 normotensive microalbuminuric type 1 (insulin-dependent) diabetic patients. After enalapril the following changes were observed: fractional albumin clearance (Θ Alb) decreased from 9.9 (3.0–23.8) to 8.2 (2.0–18.3)×10−6 (2P〈0.01); filtration fraction (FF) decreased from 0.260 (0.225–0.312) to 0.253 (0.190–0.297) (2P〈0.01); renal plasma flow (RPF) increased from 565 (411–690) to 623 (449–785) (2P〈0.01); and glomerular filtration rate (GFR) remained stable at 149 (128–181) versus 150 (124–185) ml · min−1 (NS). These values were unchanged after placebo (n=8), except for RFP which decreased from 606 (401–701) to 559 (381–677) ml · min−1 (2P〈0.05) and GFR which was reduced from 148 (111–173) to 138 (111–167) (2P〈0.05). A reduction in mean blood pressure from 94 (87–103) to 89 (79–101) mmHg (2P〈0.05) was found in the enalapril group and a minor reduction in the placebo group from 97 (83–106) to 96 (81–104) mmHg (2P〈0.05) was also noted. The relative changes in systolic blood pressure in the enalapril group correlated with changes in Θ Alb (Spearman'sr=0.66, 2P〈0.02) and FF (r=0.53, 2P〈0.05). Acute inhibition of angiotensin converting enzyme does not reduce the pathological hyperfiltration in these patients and a reduction in Θ Alb and FF can not be dissociated from the reduction in blood pressure.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00572859
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