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  • 1
    Electronic Resource
    Electronic Resource
    Corticosteroid response to stress depends upon increased tryptophan availability (1983)
    Springer
    Psychopharmacology 79 (1983), S. 79-81 
    Details
    ISSN: 1432-2072
    Keywords: Corticosteroid response to stress ; Tryptophan availability ; Amino acids ; 5HT synthesis ; Tryptophan ; Tyrosine ; Valine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Prior administration of valine to rats has been shown previously to prevent restraint stress-induced increases in brain tryptophan and 5HT turnover. The present study demonstrates that the accompanying attenuation of the corticosteroid response to this stress is substantially reversed by administration of tryptophan with the valine. Tyrosine is not effective in reversing this attenuation, and in fact itself attenuates the corticosteroid response to the stress when given alone. It is concluded that at least part of the corticosteroid response to restraint stress is mediated by an increase in serotonergic activity that is dependent on increased supply of the precursor, tryptophan, and that this can be antagonised by either of two amino acids which compete with tryptophan for access to the brain. Implications for stress-associated human disorders are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433020
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Direct cleavage of the vicinal diol linkage of the lignin model compound dihydroanisoin by the basidiomycete Phanerochaete chrysosporium (1983)
    Springer
    Archives of microbiology 134 (1983), S. 299-302 
    Details
    ISSN: 1432-072X
    Keywords: Phanerochaete chrysosporium ; Vicinal diol cleavage ; Lignin model compounds ; Dihydroanisoin ; Anlsyl alcohol ; White rot basidiomycete ; Anisaldehyde ; Cytochrome P-450 ; Activated oxygen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The white rot basidiomycete Phanerochaete chrysosporium metabolized dihydroanisoin (1,2-dianisylethane-1,2 diol) in low nitrogen stationary cultures, conditions under which the ligninolytic system is expressed. Anisyl alcohol was isolated as a metabolic product indicating an initial diol bond cleavage of the substrate. Use of 3H-labeled dihydroanisoin (1,2-dianisylethane-1,2-diol-1,2 3H) indicated that the diol bond was cleaved directly, yielding anisyl aldehyde as the initial product. The metabolically stable ketol anisoin was shown not be an intermediate in the metabolism of dihydroanisoin. The diol cleavage reaction was dependent on the concentration of molecular oxygen but O2 could be replaced by H2O2 under some conditions. The cleavage reaction was inhibited by exogenously-added tyrosine2-Cu2+ complex (TCC). The appearance of the fungal diol cleavage system parallels the appearance of the ligninolytic system under a variety of physiological conditions. In addition, preincubation of ligninolytic cultures with 2.5 mM l-glutamate represses both the ligninolytic and the diol cleavage activities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00407806
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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