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  • 1
    ISSN: 1432-2072
    Keywords: Morphine ; Physical Dependence ; Secondary Reinforcement ; Etonitazene ; Addiction ; Anise-Flavor ; Relapse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 1. On 9 nights (2000-0800) over a 25-day period, an anise-flavored aqueous solution of etonitazene, 5 mcg/ml, was provided as the sole drinking fluid for one group of physically dependent rats (MFETZ) maintained on morphine, 200 mg/kg i.p. once daily at 0800 (hence acutely abstinent each night) and for one group of saline-injected rats (SFETZ), while only anise-flavored water was available to comparable physically dependent (MFH2O) and saline-injected (SFH2O) groups. 2. Beginning 3 days after abrupt and permanent termination of morphine or saline injections, all rats were tested at intervals over a period of 287 days on nocturnal (2000-0800) choice drinking from 2 tubes (positions alternated), one contained anise-flavored water and the other, plain water. 3. Analyses of variance on the mean volumes of each of the two fluids consumed by each rat over blocks of choice-drinking tests revealed that through the VIIth test (137th post-injection day), MFETZ drank more anise-flavored water than any other group while there were no significant differences among the groups as regards consumption of plain water. 4. The evidence indicates that the potency of secondary reinforcers so generated can persist long after morphine withdrawal. Some implications for problems of relapse and treatment of opioid addicts are discussed.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0009-2940
    Keywords: Lanthanides ; Benzamidinate ligands ; Steric cyclopentadienyl equivalents ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Steric Cyclopentadienyl Equivalents in f-Element Chemistry: Monomeric, Homoleptic Lanthanide(III) Tris[N,N′-bis(trimethylsilyl)benzamidinates]Anhydrous lanthanide trichlorides react with N-silylated sodium benzamidinates, Na[4-RC6H4C(NSiMe3)2], (1a-d), to give the monomeric, homoleptic lanthanide(III) benzamidinates [4-RC6H4C(NSiMe3)2]3Ln (2-23, R = H, MeO, CF3, Ph). The molecular structure of [4-MeOC6H4C(NSiMe3)2]3Pr (11) has been determined by X-ray diffraction. Absorption and emission measurements reveal that the three benzamidinate ligands produce an unusually large crystal field which is comparable with that of cyclopentadienyl.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 34 (1995), S. 2466-2488 
    ISSN: 0570-0833
    Keywords: cyclooctatetraene complexes ; homogeneous catalysis ; lanthanides organolanthanide compounds ; Cyclooctatetraenes ; Homogeneous catalysis ; Lanthanides ; Organolanthanides ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: During the past ten years the organometallic chemistry of the lanthanides has witnessed enormous growth. One of the main reasons for this development was the finding that lanthanide metallocenes can exhibit an unusually high catalytic activity. Considerable advances have also been achieved in the chemistry of organolanthanide complexes that are not stabilized by cyclopentadienyl ligands. For example, the successful synthesis of the first unsolvated homoleptic trialkyllanthanides, [Ln{CH(SiMe3)2}3], has recently been reported. Anionic allyl complexes of the lanthanides show promising catalytic properties and cyclooctatetraene complexes of these elements are also under active investigation. This review is intended to provide an overview of this rapidly developing area of research.
    Additional Material: 37 Ill.
    Type of Medium: Electronic Resource
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