ISSN:
1420-9071
Keywords:
Gigantecin
;
acetogenins
;
Goniothalamus giganteus
;
Annonaceae
;
brine shrimp
;
antimitotic
;
cytotoxic
;
crown gall tumors
;
potato disc assay
;
9 ASK
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Gigantecin (I), a novel tetrahydroxy-di-tetrahydrofuran fatty acid γ-lactone (acetogenin), was isolated from an ethanolic extract of the stem bark ofGoniothalamus giganteus Hook. f., Thomas (Annonaceae), by means of activity-directed fractionation (brine shrimp lethality test). This new compound is extremely cytotoxic to human tumor cells, inhibits crown gall tumors on potato discs, and is active in an assay designed to detect antimitotic agents (9 ASK).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01954260
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