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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 239 (1992), S. 147-151 
    ISSN: 1432-1459
    Keywords: Neuropathy ; Paraproteinemia ; Cold agglutinin ; Anti-Pr2 antibody ; Ganglioside
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of ataxic neuropathy associated with IgMκ M proteinemia is reported. Double filtration plasmapheresis effectively treated the neuropathy. The IgMκ antibody had anti-Pr2 cold agglutinin activity. We demonstrated reactivities of the IgMκ antibody to sialosyl paragloboside, sialosyl lactosaminyl paragloboside, GT1b, GD1a, GD1b, GM3 and GD3 on high-performance thin-layer chromatography immunostaining and enzyme-linked immunosorbent assay, which is previously unreported antigenic specificity of the M proteins in cases of para proteinemic neuropathy. IgM M protein with anti-Pr2 cold agglutinin activity may play a pathogenetic role in peripheral nerve demyelination, because the target antigens of the M protein are present in myelin and possibly in endothelial cells of the peripheral nervous system.
    Type of Medium: Electronic Resource
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