ISSN:
1434-0879
Keywords:
Chorioallantoic membrane
;
Anticancer agents
;
Hyperthermia
;
thermo-chemotherapy
;
Sensitivity test
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The chorioallantoic membrane of chick embryos was used to examine the responses of three tumour cell lines to anticancer agents, alone and in combination with hyperthermia. Fifteen minutes of hyperthermia at 42.5°C produced the most favourable anticancer effect in the B 16-F 10 grafts. The use of Adriamycin (ADM) alone and the combined use of hyperthermia and either cisplatin (CDDP), cyclophosphamide (CY) or ADM resulted in a significantly higher rate of tumour regression in the B 16-F 10 grafts from a murine melanoma. In the KK-47 grafts derived from a transitional cell carcinoma of the bladder, the use of CY alone and the combination of CY and hyperthermia produced a significant tumour regression rate. In the T24 grafts neither the use of CY or CDDP alone, nor the combination of these drugs with hyperthermia demonstrated any significant effect. This method of screening anticancer agents was found to be rapid, simple to perform and inexpensive.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00299724
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