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  • 1
    Electronic Resource
    Electronic Resource
    Antimutagenic unusual amino acids from plants (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 1622-1623 
    Details
    ISSN: 1420-9071
    Keywords: Antimutagens ; natural product ; unusual amino acids ; isolation and structural determination ; Liliaceae ; Sapindaceae ; Salmonella typhimurium TA100
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Five unusual amino acids were identified as antimutagens against spontaneous mutation ofSalmonella typhimurium TA100: L-azetidine-2-carboxylic acid (1) from Liliaceae plants, α-(methylenecyclopropyl)glycine (2) fromLitchi chinensis seeds, and 2-amino-4-methylhex-5-ynoic acid (3), hypoglycin A (4), and (2S, 4R)-2-amino-4-hydroxyhept-6-ynoic acid (5) fromEuphoria longana seeds. The absolute stereochemistry of5 was determined by its chiral synthesis from L-allylglycine, proving that5 is the C-4 epimer of the amino acid previously isolated from dried longan seeds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964840
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Promoting effect of sodium chloride in 2-stage urinary bladder carcinogenesis in rats initiated by N-Butyl-N-(4-hydroxybutyl)-nitrosamine (1986)
    Springer
    Urological research 14 (1986), S. 201-206 
    Details
    ISSN: 1434-0879
    Keywords: Rat bladder carcinogenesis ; Initiation and promotion ; N-Butyl-N-(4-hydroxybutyl)nitrosamine ; Urinary composition ; Sodium chloride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The promoting effect of sodium chloride (NaCl) in 2-stage urinary bladder carcinogenesis in F344 rats initiated by 2 doses of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) was investigated. The incidences of PN hyperplasia were significantly higher in rats initiated with 0.01 or 0.05% BBN when they were given diet containing 10% NaCl for 32 weeks than when they were given control diet. The incidence of papilloma in rats given 0.05% BBN followed by diet containing 10% or 5% NaCl tended to be higher than that in control rats. The urine of rats given diet containing NaCl was larger in volume and had lower osmolality than that of controls. The total urinary sodium and chloride contents were also increased, whereas those of potassium and phosphorus were decreased. No calculus formation or crystalluria was observed. These data suggest that excess intake of sodium as NaCl has a weak promoting effect in 2-stage urinary bladder carcinogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441114
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    Paper (German National Licenses)
    Fulltext
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