ISSN:
0009-2940
Keywords:
Antitumor agents
;
Nucleotides
;
Palladium
;
Hydrogen bonds
;
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The compound [Pd(en)(5′-IMP-N7)2].11 H2O, where 5′-IMP = inosine 5′-monophosphate, crystallizes in the tetragonal space group P4322 with the unit cell parameters: a = b = 12.060(5) and c = 28.510(5) Å, V = 4147(3) Å3, Z = 4. A head-to-tail orientation with A configuration is observed for the nucleotides which are coordinated through the N(7) positions such that d[Pd-N(7)] = 2.053(8) Å. The sugar moieties exhibit anti orientations toward the purine bases while their pukkers adopt C(3)′-endo conformation. The overall conformation about the phosphate backbone is gauche+. Intramolecular hydrogen bonding is observed between the phosphates and the NH groups of the en ligand with a donor-acceptor distance of 2.88 Å. The coordination mode of the solid-state structure is shown to be identical to that observed by 1H-NMR spectroscopy in solution under slightly acidic conditions, where the N (l) positions of the nucleotides are protonated. The results are discussed in reference to closely related systems reported in the literature with emphasis on the importance of hydrogen bonding in such complexes.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19971301032
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