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  • Antitumoral activities  (1)
  • Computed tomography of musculoskeletal neoplasms  (1)
  • Paediatric radiology  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Small intestine biopsy of children with coeliac disease: Influence of X-ray equipment on radiation dosage (1994)
    Springer
    European radiology 4 (1994), S. 458-461 
    Details
    ISSN: 1432-1084
    Schlagwort(e): Radiation dose ; Paediatric radiology ; X-ray equipment ; Intestinal biopsy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In paediatric radiology intestinal biopsies for the diagnosis of coeliac disease are performed using fluoroscopy. The radiation exposure to the child depends on the X-ray equipment. We report patient measurements from three different equipments (A, B and C) together with a phantom study simulating children of different thickness relative to age. The median values of the mean absorbed dose to the child in the irradiated volume were 1.2 mGy (A), 0.79 mGy (B) and 0.15 mGy (C). The results show that the increase in tube potential with increasing distance in one equipment decreases the dosage, and also that modern equipment should be employed. Particularly old image intensifiers should not be used. With an optimal choice of equipment the dosage to the child can be reduced fourfold. The combination of an optimal technique of sedation and an experienced operator can reduce the dosage tenfold.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00212821
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    7-Hydroxycoumarin inhibits oncogene-induced transformation of murine fibroblasts (1994)
    Springer
    Journal of cancer research and clinical oncology 120 (1994), S. S23 
    Details
    ISSN: 1432-1335
    Schlagwort(e): 7-Hydroxycoumarin ; Antitumoral activities ; Oncogene ; Transformation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract 7-Hydroxycoumarin (7-HC) is a naturally occuring substance with a variety of biological activities, e.g. antitumoral and immunomodulatory action. the potential mechanisms of 7-HC action on tumor cells have been investigated in a model of mouse fibroblasts transformed by distinet retroviral vectors carrying the oncogenesmyc andras. Treatment of the different oncogenic transformants with 7-HC in non-cytotoxic concentrations causes a strong inhibition of their proliferative capacity as measured by growth curves. Furthermore, incubation of theras andmyc transformants with 7-HC abrogated soft agar colony formation when compared to untreated cultures. These changes in cell growth characteristics of the various oncogene-transformed mouse fibroblasts were transient, since removal of 7-HC from the cultures caused a reappearance of the transformed properties of these cells within 6 days. The 7-HC-mediated inhibition of the proliferative capacity of the transformants was preceded by a selective down-regulation of oncogene expression. These data suggest that 7-HC causes a reversible inhibition ofras- andmyc-induced neoplastic properties in transformed fibroblasts by selective down-regulation of retroviral RNA levels.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01377119
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  • 3
    Digitale Medien
    Digitale Medien
    Magnetic resonance imaging of bone and soft tissue tumors: Early experience in 31 patients compared with computed tomography (1985)
    Springer
    Skeletal radiology 13 (1985), S. 134-146 
    Details
    ISSN: 1432-2161
    Schlagwort(e): Magnetic resonance imaging ; Musculoskeletal neoplasms ; Computed tomography of musculoskeletal neoplasms
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In 31 patients with 21 soft tissue and 10 bone tumors, magnetic resonance imaging (MRI) and computed tomography (CT) were equally effective in delineating the margins of most soft tissue tumors, and the margins of bone tumors from fat and adjacent normal bone. However, MRI was superior to CT in delineating bone tumors from adjacent muscle, and in showing the relationships to bone of the deep margins of some soft tissue tumors. This was true because the quality of CT images around thick cortical bone often was severely degraded by streak artifact, which does not occur in MRI. Excellent anatomic detail was achieved on MRI by spin echo pulse sequences with short repetition times. Bone tumors were delineated best by spin echo 1000/30 images, and soft tissue tumors by spin echo 1000/30 or inversion recovery images.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00352084
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