ISSN:
1573-6830
Keywords:
human immunodeficiency virus (HIV) gp120
;
invertebrate neurons
;
Mytilus
;
Aplysia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary 1. HIV gp120 selectively reduces the glutamate-induced inward current and the acetylcholine-induced outward current in specific and identifiedAplysia neurons without affecting dopamine (DA)- and serotonin (5-HT)-induced responses. 2. gp120 specifically decreases DA levels without significantly altering norepinephrine and 5-HT levels inMytilus pedal ganglia. 3. The gp120-associated decrease in DA levels inMytilus is dose dependent and exhibits a threshold level. 4. The alteration ofin vitro DA levels is specific for gp120 since anti-gp120 blocks the effect. 5. gp120 and its effects appear to be stable due to the duration of treatment and the failure of secondary effects to materialize following antibody treatment.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00711557
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