ISSN:
1432-1440
Keywords:
Diabetes mellitus
;
Long-term diabetes
;
Lipoproteins
;
Apolipoproteins
;
HDL cholesterol
;
Triglycerides
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary All diabetic patients suffering from the disease for at least 20 years and living in the closed area of the Erfurt district in 1970 have been followed prospectively since that time. In 47 of them still alive in 1985, i.e. after more than 35 years of diabetes, serum lipid and apolipoprotein concentrations were measured and compared to those of non-diabetic subjects without cardiovascular diseases (n=47) pair-matched by sex, age, and body weight. In males (n=27) significantly (p〈0.01) higher levels of HDL cholesterol and apolipoprotein A–I as well as lower concentrations of triglycerides and a lower total cholesterol/HDL cholesterol risk ratio than in nondiabetic control subjects could be found. In long-term diabetic females (n=20), apolipoprotein A–I levels were also increased (p〈0.02). Trends in HDL cholesterol and triglycerides were similar to those found in males but did not reach statistical significance. Higher concentrations of total cholesterol (p〈0.02), LDL cholesterol (P〈0.05), and apolipoprotein B (p〈0.02), however, did not fit in with a beneficial lipoprotein pattern. The frequency of pathological lipoprotein patterns was not higher than among the non-diabetic control subjects (32% and 40%, respectively). According to these findings an antiatherogenic lipoprotein pattern might be considered, at least in males, as one of the determinants causing the multifactorial event of long-term survival in diabetes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01726929
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