ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Oxidative modification of lens crystallins by H"2O"2 and chelated iron

Samuel Zigler, J. ; Huang, Q.-L. ; Du, X.-y.

Amsterdam : Elsevier

Free Radical Biology and Medicine 7 (1989), S. 499-505

add to mindlist on the mindlist

Details

ISSN: 0891-5849

Keywords: Fenton reaction ; Free radicals ; H"2O"2 ; Lens crystallins ; Oxidation ; Protein modification ; hydroxyl radical

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Medicine

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0891-5849(89)90025-7

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Evaluation of the BCL-2 gene locus as a susceptibility locus linked to the clinical expression of systemic lupus erythematosus (SLE) (1996)

Huang, Q. R. ; Morris, D. ; Manolios, N.

Springer

Rheumatology international 16 (1996), S. 121-124

add to mindlist on the mindlist

Details

ISSN: 1437-160X

Keywords: SLE ; Apoptosis ; bcl-2 gene ; Susceptibility ; Linkage ; Genetics

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the production of a large number of autoantibodies. It has been postulated that this may be the result of prolonged longevity of auto-reactive B cells due to defective regulation of programmed cell death (apoptosis). The proto-oncogenebcl-2 is involved in the control of apoptosis in immunocompetent cells, and its over-expression is noted in T and B cells from SLE patients. This study examined the genetic linkage between thebcl-2 gene locus and SLE susceptibility using the affected sib-pair method in SLE families. Seventeen caucasian multiplex families were evaluated. A polymorphic microsatellite marker closely linked to thebcl-2 gene on 18g21.3 was used to determine thebcl-2 genotype. We demonstrated that haplotype sharing among the affected sibling pairs was not statistically different from random (P〉0.5). This suggests that thebcl-2 gene locus does not confer a genetic susceptibility to SLE expression.