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  • Arotinoid  (1)
  • Baboon malignant lymphoma  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Morphological characteristics of malignant T-cell lymphomas in baboons (1993)
    Springer
    Virchows Archiv 422 (1993), S. 109-120 
    Details
    ISSN: 1432-2307
    Keywords: Baboon malignant lymphoma ; Peripheral T-cell lymphoma ; Simian T-cell leukaemia virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fifteen cases of generalized peripheral T-cell non-Hodgkin's lymphoma in baboons were phenotyped immunologically and morphologically. Using the updated Kiel classification the cases included low-grade and high-grade lymphomas and low-grade lymphomas that had transformed into high-grade lymphomas. In the low-grade group there were seven cases of lymphocytic type, partly corresponding to chronic lymphocytic leukaemia of T type and to T-zone lymphoma in man. In addition there were four cases of prolymphocytic-lymphocytic type, which show large nodules (“proliferation centres”) and which have no equivalent in the Kiel classification. In four cases there was a progression to an immunoblastic lymphoma and in one case to a large cell anaplastic lymphoma. In addition, three cases of large cell anaplastic lymphoma without a low-grade component were found. Both the immunoblastic lymphomas and the large cell anaplastic lymphomas corresponded well with the same types in the Kiel classification. The cases of large cell anaplastic lymphoma were also CD30 positive. Most of these lymphomas were CD4 positive, but there were rare cases that were either CD8 positive, showed both CD4 and CD8 positivity or had lost both antigens. Antigens associated with cell activation were often revealed. All but one baboon had antibodies in the blood against the retrovirus STLV-1 (simian T-cell leukaemia virus 1), which is very similar to human T-cell leukaemia virus 1 (HTLV-1) in man. Despite this virological resemblance, the morphology of these T-cell lymphomas does not resemble that of the HTLV-1-positive Japanese T-cell lymphomas but is like that of the HTLV-1-negative European cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01607162
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Sebum-suppressing activity of the nonpolar arotinoid Ro 15-0778 in rodents (1988)
    Springer
    Archives of dermatological research 280 (1988), S. 246-251 
    Details
    ISSN: 1432-069X
    Keywords: Retinoids ; Sebum ; Arotinoid ; Hypervitaminosis A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Retinoids are known to modulate sebaceous gland activity in humans and animals. The nonpolar arotinoid Ro 15-0778 [(E)-1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-(1-methyl-2-phenylethenyl) naphthalene] does not contain a polar end group and is devoid of the classical retinoid side effects of hypervitaminosis A. The favorable toxicological profile stimulated the evaluation of this arotinoid in animal models of sebum production. In castrated, testosterone-stimulated male rats, Ro 15-0778 is 50 times more potent than 13-cis-retinoic acid in inhibiting the production and subsequent secretion of sebum. The oral ED50 value of Ro 15-0778 is 30μg/kg, while an oral dose of 0.5 mg/kg inhibited sebum secretion nearly 1005. In testosterone-stimulated female rats, Ro 15-0778 inhibits sebum secretion significantly with an oral ED50 of 140 μg/kg and an s.c. ED50 of 75μg/kg. Ro 15-0778 was also evaluated for its ability to prevent testosterone induction of the immature hamster flank organ. The topical ED50 is 0.53 mg/kg and the oral ED50 is 38 mg/kg. This arotinoid is similarly active in mature male hamsters without testosterone treatment. In addition, the retinoid is active topically and orally in reducing the size of the gerbil abdominal sebaceous gland. The compound exhibits no antiandrogenic activity when tested in ventral prostrate and seminal vesicle assays in rats. Additionally, the compound does not have estrogenic activity when tested in the rat uterine weight assay. High doses of Ro 15-0778 in humans did not demonstrate significant sebumsuppressing activity. This study indicates that extra-polation of retinoid data from rodent animal models to activity in human sebaceous glands can not be made with a high degree of certainty. There is a need to develop new, more predictive models for retinoid activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00513964
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    Paper (German National Licenses)
    Fulltext
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